Development of pluronic F127 and folic acid coated TiO2nanoparticles for antimicrobial and anticancer applications
- Title
- Development of pluronic F127 and folic acid coated TiO2nanoparticles for antimicrobial and anticancer applications
- Creator
- Kunal; Rai, Keerti; Pradhan, Sanghamitra; Sellamuthu, Prabhukumar; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A.
- Description
- Functionalizing metal oxide nanoparticles with polymers and folic acid enhances eco-friendly synthesis, therapeutic efficiency, and cost-effectiveness. This study reports the green synthesis of titanium dioxide (TiO?) and folic acidPluronic F127modified TiO?(TiPFFA) nanoparticles usingPsidium guajavaleaf extract as a natural reducing and stabilizing agent. X-ray diffraction (XRD) analysis confirmed that both nanoparticles crystallized in the rutile phase. Morphological characterization by FESEM and TEM showed that the nanoparticles were spherical with uniform size distribution. FTIR spectroscopy showed TiOTi (789cm?1) and TiO (666cm?1) for TiO?; TiPFFA had extra peaks at 951 and 640cm?1, confirming the lattice. PL spectra exhibited emission peaks at 518nm (TiO?) and 520nm (TiPFFA), indicating oxygen vacancies linked to reactive oxygen species generation. Antimicrobial tests against methicillin-resistantStaphylococcus aureus andCandida albicansshowed superior activity of TiPFFAnanoparticles compared to TiO?. Cytotoxicity assays on MDA-MB-231 breast cancer cells and L929 fibroblast cells demonstrated enhanced anticancer activity and better biocompatibility for TiPFFA. These findings highlight TiPFFA nanoparticles as promising candidates for targeted cancer therapy and as antimicrobial agents. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.
- Source
- Naunyn-Schmiedeberg's Archives of Pharmacology;Volume;399;Issue;3;pp.3533-3544
- Date
- 01-01-2026
- Publisher
- Springer Science and Business Media Deutschland GmbH
- Subject
- Cytotoxicity; Folic acid; Methicillin-resistant; Pluronic F127; Titanium dioxide
- Coverage
- Kunal, Department of Life Sciences, Faculty of Allied Health Sciences, SGT University, Haryana, Gurugram, India; Rai K., Department of Electrical & Electronics, ARKA JAIN University, Jharkhand, Jamshedpur, India; Pradhan S., Department of Chemistry, Siksha ?O Anusandhan (Deemed to Be University), Odisha, Bhubaneswar, 751030, India; Sellamuthu P., Department of Mechanical Engineering, Presidency University, Karnataka, Bengaluru, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to Be University), Karnataka, Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Bhran A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia
- Rights
- Restricted Access; Hardcopy may be available in the library
- Relation
- ISSN: 281298; CODEN: NSAPC
- Format
- online
- Language
- English
- Type
- Article
Collection
Citation
Kunal; Rai, Keerti; Pradhan, Sanghamitra; Sellamuthu, Prabhukumar; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A., “Development of pluronic F127 and folic acid coated TiO2nanoparticles for antimicrobial and anticancer applications,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/21834.