Chitosan coated multifunctional NiFe?O? nanocomposites as a promising candidate for biomedical applications
- Title
- Chitosan coated multifunctional NiFe?O? nanocomposites as a promising candidate for biomedical applications
- Creator
- Thangavelu, Indumathi; Tadepalli, Srinivas
- Description
- Nanoparticles for biomedical applications often suffer from limited stability, low biocompatibility, and suboptimal therapeutic efficacy. To address these challenges, NiFe?O? nanoparticles were functionalized with chitosan (NiFe?O?-CS) via a co-precipitation method, aiming to enhance their structural, optical, antimicrobial, and anticancer properties. XRD analysis revealed a reduction in crystallite size from 37 to 33nm after chitosan modification, indicating controlled crystal growth and increased surface area. TEM results confirmed a corresponding decrease in particle size from 35 2.1nm to 29 1.8nm, improving surface reactivity and stability. PL spectra exhibited a red-shift in green emission peaks, suggesting increased oxygen vacancies and defect states that facilitate ROS generation. Antimicrobial assays against methicillin-resistant Staphylococcus aureus (MRSA) and Candida albicans (C.albicans) demonstrated significantly higher activity for NiFe?O?-CS nanocomposites, supported by SEM imaging that showed extensive microbial membrane disruption. Furthermore, NiFe?O?-CS exhibited enhanced anticancer activity against C6 glioma cells, with an IC?? of 35.6g/mL compared to 43.6g/mL for unmodified nanoparticles. Zebrafish embryo studies confirmed the biocompatibility of NiFe?O?-CS at appropriate doses, although dose-dependent embryotoxicity was observed. These findings highlight that chitosan functionalization of dual-metal nanoparticles improves therapeutic efficacy through increased surface interactions and ROS generation while underscoring the need for careful dose optimization. This study presents a novel strategy for designing biopolymer-coated nanocomposites that balance enhanced biomedical performance with safety considerations. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2026.
- Source
- Naunyn-Schmiedeberg's Archives of Pharmacology;
- Date
- 01-01-2026
- Publisher
- Springer Science and Business Media Deutschland GmbH
- Subject
- Biocompatibility; Embryotoxic; Glioma cancer; MRSA; NiFe2O4; Zebrafish
- Coverage
- Thangavelu I., Department of Chemistry, CHRIST (Deemed to Be University), Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), 11432, Riyadh, Saudi Arabia
- Rights
- Restricted Access; Hardcopy may be available in the library
- Relation
- ISSN: 281298; CODEN: NSAPC
- Format
- online
- Language
- English
- Type
- Article
Collection
Citation
Thangavelu, Indumathi; Tadepalli, Srinivas, “Chitosan coated multifunctional NiFe?O? nanocomposites as a promising candidate for biomedical applications,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/21835.