Synthesis and characterization of NiTiO?L-ornithine nanoparticles and their antibacterial, antifungal, antioxidant activities, and zebrafish biocompatibility
- Title
- Synthesis and characterization of NiTiO?L-ornithine nanoparticles and their antibacterial, antifungal, antioxidant activities, and zebrafish biocompatibility
- Creator
- Sandilya, Manabendra; Sahu, Pratap Kumar; Pasha, Mahaboob; Bhasin, Menka; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A.
- Description
- The increasing prevalence of antimicrobial resistance and biofilm-associated infections demands multifunctional nanomaterials with improved efficacy and safety. In this study, defect-engineered nickel titanate (NiTiO?) nanoparticles functionalized with L-Ornithine (NiTiO?LO) were synthesized via a co-precipitation approach to enhance antimicrobial performance while maintaining biocompatibility. XRD analysis confirmed phase-pure rhombohedral NiTiO? with reduced crystallite size upon functionalization (31.3 2nm to 26.2 2nm). XPS and FTIR analyses verified successful LO surface coordination and modulation of oxygen vacancyrelated defect states. PL studies revealed defect-mediated green emissions (507529nm), indicating stabilized oxygen vacancies after functionalization. NiTiO?LO exhibited significantly enhanced antibacterial and antifungal activity, with inhibition zones of 17.9 0.4mm and 18.9 0.4mm, respectively. The nanoparticles also demonstrated concentration-dependent antioxidant activity, achieving ~ 63% DPPH scavenging at 100g/mL, comparable to Vitamin C (~ 65%). Importantly, zebrafish embryo assays showed no observable developmental toxicity, indicating favourable in vivo biocompatibility. These findings establish NiTiO?-LO as a defect-modulated, multifunctional nanoplatform integrating antimicrobial, antioxidant, and biocompatible properties for potential biomedical applications. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2026.
- Source
- Naunyn-Schmiedeberg's Archives of Pharmacology;
- Date
- 01-01-2026
- Publisher
- Springer Science and Business Media Deutschland GmbH
- Subject
- Antimicrobial activity; Antioxidant; Biocompatibility; LO; NiTiO3
- Coverage
- Sandilya M., Department of Biomedical Engineering, Faculty of Engineering and Technology, Parul Institute of Technology, Parul University, Gujarat, Vadodara, 391760, India; Sahu P.K., Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to Be University), Odisha, Bhubaneswar, 751030, India; Pasha M., Department of Physics, Presidency University, Karnataka, Bengaluru, 560064, India; Bhasin M., Department of FBAS (Chemistry), Vivekananda Global University, Jaipur, 303012, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to Be University), Karnataka, Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Bhran A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia
- Rights
- Restricted Access; Hardcopy may be available in the library
- Relation
- ISSN: 281298; CODEN: NSAPC
- Format
- online
- Language
- English
- Type
- Article
Collection
Citation
Sandilya, Manabendra; Sahu, Pratap Kumar; Pasha, Mahaboob; Bhasin, Menka; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A., “Synthesis and characterization of NiTiO?L-ornithine nanoparticles and their antibacterial, antifungal, antioxidant activities, and zebrafish biocompatibility,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/21836.