Pluronic F127-functionalized cerium fluoride nanocomposite: synthesis, characterization, and its enhanced antibacterial activities
- Title
- Pluronic F127-functionalized cerium fluoride nanocomposite: synthesis, characterization, and its enhanced antibacterial activities
- Creator
- R, Shashikala A.; Chaudhary, Sarita; Adil, Shaikh; Rout, Sudhanshu; Thangavelu, Indumathi; Tadepalli, Srinivas; Gadallah, Abdelrahman G.
- Description
- The persistence of pathogenic bacteria, rising antibiotic resistance, and the ongoing need for effective anticancer agents necessitate the development of advanced multifunctional therapeutic strategies. In this study, CeF? nanoparticles and PF127-functionalized CeF? (CeF?PF127) nanocomposites were synthesized via a facile wet chemical route and systematically characterized for their structural, optical, and biological properties. XRD confirmed the formation of phase-pure hexagonal CeF? with crystallite sizes of 31nm (CeF?) and 27nm (CeF?PF127), while SAED revealed lattice fringes of approximately 0.27nm (CeF?) and 0.29nm (CeF?PF127). EDAX and XPS validated the Ce/F stoichiometry and the successful surface functionalization with PF127. Optical analyses showed a slight reduction in band gap from 3.15 to 3.09eV upon polymer coating, and PL spectra indicated enhanced defect-related emission in CeF?PF127, suggesting stabilization of Ce3? ions and oxygen vacancy sites. Biological evaluations demonstrated that CeF?PF127 exhibited superior antioxidant activity (DPPH assay) and enhanced anticancer efficacy against MG-63 osteosarcoma cells, with lower IC?? values over 2472h. Antibacterial studies against S. aureus, B. subtilis, K. pneumoniae, and S. dysenteriae revealed larger inhibition zones (1820.5mm) and improved MIC/MBC values (600/1000gmL?1) compared to bare CeF?. Biocompatibility assessment using L929 fibroblasts confirmed cell viability exceeding 80% for both samples. Collectively, these results demonstrate that CeF?PF127 is a stable, multifunctional nanocomposite with promising potential for biomedical applications. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2026.
- Source
- Naunyn-Schmiedeberg's Archives of Pharmacology;
- Date
- 01-01-2026
- Publisher
- Springer Science and Business Media Deutschland GmbH
- Subject
- Antibacterial and anticancer activity; Antioxidant properties; Biocompatible nanomaterials; CeF? nanoparticles; CeF?PF127 nanocomposite
- Coverage
- R S.A., Department of Chemistry, Presidency University, Karnataka, Bengaluru, 560064, India; Chaudhary S., Department of FBAS (Chemistry), Vivekananda Global University, Jaipur, 303012, India; Adil S., Department of Dairy Technology, Faculty of Engineering and Technology, Parul Institute of Technology, Parul University, Gujarat, Vadodara, 391760, India; Rout S., Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to Be University), Odisha, Bhubaneswar, 751030, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to Be University), Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Gadallah A.G., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia
- Rights
- Restricted Access; Hardcopy may be available in the library
- Relation
- ISSN: 281298; CODEN: NSAPC
- Format
- online
- Language
- English
- Type
- Article
Collection
Citation
R, Shashikala A.; Chaudhary, Sarita; Adil, Shaikh; Rout, Sudhanshu; Thangavelu, Indumathi; Tadepalli, Srinivas; Gadallah, Abdelrahman G., “Pluronic F127-functionalized cerium fluoride nanocomposite: synthesis, characterization, and its enhanced antibacterial activities,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/21837.