Nickel oxide modified with sodium alginate and dopamine nanoparticles for enhanced antimicrobial, antioxidant, and anticancer activity against HepG2 cells
- Title
- Nickel oxide modified with sodium alginate and dopamine nanoparticles for enhanced antimicrobial, antioxidant, and anticancer activity against HepG2 cells
- Creator
- Siddhartha, Marupati; Ahlawat, Shruti; Sahu, Chandra Prabha; Krishna, Gopidesi Radha; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A.
- Description
- Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, while multidrug-resistant bacterial infections pose escalating health threats. To address these challenges, nickel oxide nanoparticles (NiO Nanoparticles) and sodium alginatedopamineNiO-SA-Dop nanoparticles (NiO-SA-Dop Nanoparticles) were synthesized and extensively characterized for multifunctional biomedical applications. X-ray diffraction revealed crystallite sizes of 40.6nm (NiO) and 29.76nm (NiO-SA-Dop). Transmission electron microscope analysis confirmed spherical morphology with reduced particle size upon modification, supporting improved surface properties. UVvisible spectroscopy showed band gap energies of 4.15eV (NiO) and 4.44eV (NiO-SA-Dop). Photoluminescence spectra indicated enhanced green emission in NiO-SA-Dop, suggesting a higher concentration of oxygen vacancies Linked to increased reactive oxygen species Generation. In functional assays, NiO-SA-Dop demonstrated superior free radical scavenging efficiency in the 2,2-diphenyl-1-picrylhydrazyl assay compared to NiO. Strong antibacterial activity was observed against Gram-negative pathogens including Pseudomonas aeruginosa, Klebsiella pneumoniae, Vibrio cholerae, Escherichia coli, and Shigella dysenteriae. Cytotoxicity assays against HepG2 cells yielded IC?? values of 11.9g/mL for NiO and 10.3g/mL for NiO-SA-Dop, underscoring the enhanced anticancer efficacy of the modified nanoparticles. Overall, NiO-SA-Dop Nanoparticles exhibit promising antibacterial, antioxidant, and anticancer activities, making them strong candidates for advanced therapeutic development. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.
- Source
- Naunyn-Schmiedeberg's Archives of Pharmacology;Volume;399;Issue;2;pp.3017-3033
- Date
- 01-01-2026
- Publisher
- Springer Science and Business Media Deutschland GmbH
- Subject
- Antibacterial activity; Cancer therapy; Cytotoxicity HepG2 cells; DPPH radical scavenging; NiO; NiO-SA-Dop; Reactive oxygen species
- Coverage
- Siddhartha M., Department of Chemistry, Vardhaman College of Engineering, Hyderabad, India; Ahlawat S., Department of Life Sciences, Faculty of Allied Health Sciences, SGT University, Haryana, Gurugram, India; Sahu C.P., Department of Electrical & Electronics, ARKA JAIN University, Jharkhand, Jamshedpur, India; Krishna G.R., Department of Mechanical Engineering, Presidency University, Karnataka, Bengaluru, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to Be University), Karnataka, Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Bhran A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia
- Rights
- Restricted Access; Hardcopy may be available in the library
- Relation
- ISSN: 281298; CODEN: NSAPC
- Format
- online
- Language
- English
- Type
- Article
Collection
Citation
Siddhartha, Marupati; Ahlawat, Shruti; Sahu, Chandra Prabha; Krishna, Gopidesi Radha; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A., “Nickel oxide modified with sodium alginate and dopamine nanoparticles for enhanced antimicrobial, antioxidant, and anticancer activity against HepG2 cells,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/21833.