Design and characterization of SrO2-CMC-Dcar nanocomposite with enhanced antimicrobial, anticancer, and antioxidant activities
- Title
- Design and characterization of SrO2-CMC-Dcar nanocomposite with enhanced antimicrobial, anticancer, and antioxidant activities
- Creator
- Thakore, Sanketsinh; Saini, Rajat; Kushwaha, Ravi kant; Asha, K.; Thangavelu, Indumathi; AlGhamdi, AbdulAziz A.; Tadepalli, Srinivas
- Description
- HeLa cervical cancer cells exhibit high aggressiveness and proliferation, highlighting the need for novel therapies. Nanocomposite synthesis offers a promising approach due to its enhanced bioavailability, targeted delivery, and selective cytotoxicity. Thus, carboxymethyl cellulose (CMC) and D-carvone (Dcar)-coated strontium oxide (SrO2) (SrO2-CMC-Dcar) nanocomposite were synthesized using a wet chemical method. Structural and morphological characterization using XRD, FTIR, PL spectroscopy, DLS, HRTEM, and XPS confirmed the successful synthesis of the nanocomposite. XRD analysis revealed that the crystallite sizes of SrO2 and SrO2-CMC-Dcar were 38nm and 29nm, respectively. PL spectra revealed prominent green emission at 516, 524, and 535nm, indicating that oxygen vacancies are associated with ROS generation. DLS analysis revealed that pure SrO2 exhibited a particle size distribution of 128.7nm, while the SrO2-CMC-Dcar nanocomposite showed an increased size of 244.80nm. The nanocomposite demonstrated an enhanced antimicrobial activity against MRSA and Candida albicans when compared to SrO2 alone. Furthermore, MTT assay results revealed that the SrO2CMCDcar composite significantly decreased HeLa cell viability to 11.94%, and the IC50 value was found to be 50.2 and 39.7 for SrO2 and nanocomposite SrO2-CMC-Dcar, respectively, confirming it enhanced anticancer potential. In addition, the SrO2-CMC-Dcar nanocomposite exhibited enhanced antioxidant properties demonstrated by DPPH free radical scavenging assays. These findings suggest that the SrO2-CMC-Dcar nanocomposite holds promise for therapeutic applications in combating cancer, microbial infections, and oxidative stress. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.
- Source
- Naunyn-Schmiedeberg's Archives of Pharmacology;Volume;399;Issue;1;pp.441-458
- Date
- 01-01-2026
- Publisher
- Springer Science and Business Media Deutschland GmbH
- Subject
- Antibacterial; Anticancer; Antioxidant; Nanocomposite; SrO?-CMC-Dcar
- Coverage
- Thakore S., Department of Applied Science, PIT, Parul University, Gujarat, Vadodara, India; Saini R., Centre of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, 140417, India; Kushwaha R.K., Maharishi School of Pharmaceutical Sciences, Maharishi University of Information Technology, Uttar Pradesh, Lucknow, India; Asha K., Department of Life Sciences, School of Sciences, JAIN (Deemed-to-be University), Karnataka, Bengaluru, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; AlGhamdi A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia
- Rights
- Restricted Access; Hardcopy may be available in the library
- Relation
- ISSN: 281298; CODEN: NSAPC
- Format
- online
- Language
- English
- Type
- Article
Collection
Citation
Thakore, Sanketsinh; Saini, Rajat; Kushwaha, Ravi kant; Asha, K.; Thangavelu, Indumathi; AlGhamdi, AbdulAziz A.; Tadepalli, Srinivas, “Design and characterization of SrO2-CMC-Dcar nanocomposite with enhanced antimicrobial, anticancer, and antioxidant activities,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/21832.