ItemArticle

Synthesis and Multifunctional Evaluation of BaO?-Sodium Alginate-Curcumin Nanocomposite: Improved Antibacterial, Antioxidant, and Osteosarcoma Cell Inhibition

Title
Synthesis and Multifunctional Evaluation of BaO?-Sodium Alginate-Curcumin Nanocomposite: Improved Antibacterial, Antioxidant, and Osteosarcoma Cell Inhibition
Creator
Bhalla, Vijay; Sahu, Chandra Prabha; Shashikala, A.R.; Singh, Sulochana; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A.
Description
Nanotechnology-based strategies provide a promising platform for developing multifunctional materials with enhanced antibacterial, antioxidant, and anticancer properties, offering effective solutions for combating infections, oxidative stress, and osteosarcoma cell proliferation. In the current study BaO2-sodium alginate-curcumin (BaO?-SA-Cur) was prepared by facile wet chemical route. The structural and morphological characteristics of the composite were ascertained using extensive characterization techniques. The crystallite size was found to be 52.2nm for BaO2 and 43.1nm for BaO2-SA-Cur nanocomposite as per XRD analysis. UV-visible spectroscopy results revealed that the band gap was found as 4.54eV for BaO2-SA-Cur nanocomposite and 4.38eV for BaO2 nanoparticles. PL studies revealed that the BaO2-SA-Cur nanocomposite exhibited intense emission peaks at 379nm, 421nm, 448nm, 477nm, and 508nm. DLS analysis revealed that the pure BaO2 exhibited the particle size around 118.70 5.4nm while the BaO?-SA-Cur nanocomposite around 139.50 7.8nm and more dispersion in the solution. The BaO?-SA-Cur nanocomposite exhibited enhanced antibacterial action against multi-resistant gram-negative bacterial species (Klebsiella pneumoniae, Escherichia coli, Shigella dysenteriae, Proteus vulgaris, and Pseudomonas aeruginosa) than that of pure BaO? and comparable with streptomycin. Importantly, the nanocomposite revealed remarkable anticancer activity against the osteosarcoma MG-63 cells where Cur was synergistically inducing cell apoptosis. The IC50 value was calculated as 45.7 for undoped BaO2 and 35.6 for doped BaO2-SA-Cur composite. Biocompatibility studies on L929 fibroblast cells showed over 85% cell viability for BaO?-SA-Cur, confirming its low cytotoxicity and suitability for biomedical applications. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.
Source
Journal of Inorganic and Organometallic Polymers and Materials;Volume;36;Issue;1;pp.259-278
Date
01-01-2026
Publisher
Springer
Subject
Antibacterial; Anticancer (MG-63 osteosarcoma cells); Antioxidant activities; BaO?-SA-Cur nanocomposite; PL emission
Coverage
Bhalla V., Department of Pharmaceutics, College of Pharmacy, SGT University, Haryana, Gurugram, India; Sahu C.P., Department of Electrical & Electronics, ARKA JAIN University, Jharkhand, Jamshedpur, India; Shashikala A.R., Department of Chemistry, Presidency University, Karnataka, Bengaluru, India; Singh S., Department of Chemistry, Siksha O Anusandhan (Deemed to be University), Odisha, Bhubaneswar, 751030, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Bhran A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 15741443;
Format
online
Language
English
Type
Article

Citation

Bhalla, Vijay; Sahu, Chandra Prabha; Shashikala, A.R.; Singh, Sulochana; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A., “Synthesis and Multifunctional Evaluation of BaO?-Sodium Alginate-Curcumin Nanocomposite: Improved Antibacterial, Antioxidant, and Osteosarcoma Cell Inhibition,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 19, 2026, https://archives.christuniversity.in/items/show/21914.

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