ItemArticle

Carboxymethyl Cellulose-Modified Strontium Oxide Nanoparticles: a Multifunctional Nanoplatform for C6 Glioma Therapy and Antimicrobial Applications

Title
Carboxymethyl Cellulose-Modified Strontium Oxide Nanoparticles: a Multifunctional Nanoplatform for C6 Glioma Therapy and Antimicrobial Applications
Creator
Mushtaq, Zahi; Sharma, Vijay; Mukherjee, Jonaki; Wunnava, Aneesh; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A.
Description
Glioma, a very aggressive brain tumor, poses major therapeutic challenges. The present research investigates the synthesis, characterization, and bioevaluation of carboxymethyl cellulose (CMC)-functionalized strontium oxide (SrO) nanoparticles (SrCMC) as anticancer and biocompatibility probes. SrO nanoparticles were synthesized using co-precipitation and functionalized with CMC for better dispersion and stability. Characterization by XRD, FTIR, UVVis, PL, SEM, TEM, and EDAX proved structural and optical enhancements. SrCMC showed enhanced photoluminescence with a blue shift and increased emission intensity, indicating modified surface defects. UVVis analysis revealed a slight band gap increase from 4.07eV to 4.12eV due to CMC capping. FTIR and EDAX confirmed successful functionalization, while XRD showed reduced crystallite size (32nm to 26nm) and maintained tetragonal structure. SEM and HRTEM revealed improved dispersion and decreased lattice spacing in SrCMC, reflecting surface stabilization by CMC. For in vitro tests on C6 glioma cells, the cytotoxicity was found to be time- and dose-dependent with IC?? values of 22.1, 17.6, and 14.8g/mL for SrO and 20.3, 15.8, and 12.6g/mL for SrCMC after 24, 48, and 72h respectively. In vivo biocompatibility was assessed using zebrafish embryos exposed to SrCMC nanoparticles at 0.5mg/mL and 1mg/mL across various time intervals. The agar well diffusion method was employed to assess the antimicrobial activity against the following pathogens including Gram-positive (S. pneumoniae, B. subtilis), Gram-negative (K. pneumoniae, S. dysenteriae), and fungal (C. albicans) strains. The results revealed SrCMC exhibited significant inhibitory effects against all tested organisms and comparable to streptomycin. This work shows SrCMCs potential for biomedical applications, subject to careful control of toxicity. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.
Source
Journal of Inorganic and Organometallic Polymers and Materials;Volume;35;Issue;12;pp.10290-10305
Date
01-01-2025
Publisher
Springer
Subject
Bioevaluation; Characterization; CMC-SrO nanoparticles; Synthesis; Zebrafish
Coverage
Mushtaq Z., Department of Mechanical Engineering, Presidency University, Karnataka, Bengaluru, India; Sharma V., Department of Pharmaceutics, SGT College of Pharmacy, SGT University, Haryana, Gurugram, India; Mukherjee J., Department of Electrical & Electronics, ARKA JAIN University, Jharkhand, Jamshedpur, India; Wunnava A., Electronics and Communication Engineering Department, Siksha O Anusandhan (Deemed to be University, Odisha, Bhubaneswar, 751030, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Bhran A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 15741443;
Format
online
Language
English
Type
Article

Citation

Mushtaq, Zahi; Sharma, Vijay; Mukherjee, Jonaki; Wunnava, Aneesh; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A., “Carboxymethyl Cellulose-Modified Strontium Oxide Nanoparticles: a Multifunctional Nanoplatform for C6 Glioma Therapy and Antimicrobial Applications,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 19, 2026, https://archives.christuniversity.in/items/show/21915.

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