ItemArticle

Sodium Alginate Coated Cerium(III) Fluoride Nanoparticles for Biocompatible Antimicrobial Applications: Structural and Functional Insights

Title
Sodium Alginate Coated Cerium(III) Fluoride Nanoparticles for Biocompatible Antimicrobial Applications: Structural and Functional Insights
Creator
Thangavelu, Indumathi; Ganeshkumar, P.; Saudagar, Abdul Khader Jilani
Description
Cerium(III) fluoride (CeF?) nanoparticles and sodium alignatefunctionalized CeF? nanocomposites (CeF?SA) were synthesized via a wet-chemical method. XRD confirmed phase-pure hexagonal CeF? with an average crystallite size of ~ 24nm. TEM showed uniformly distributed nanoparticles (812nm), and lattice fringe analysis revealed an interplanar spacing of ~ 0.315nm corresponding to the (111) plane, indicating preserved crystallinity after SA functionalization. UVvisible spectroscopy revealed a reduction in the optical band gap from 6.05eV (CeF?) to 4.96eV (CeF?SA), indicating modification of electronic properties. PL emission (351522nm) showed quenching, suggesting suppressed charge carrier recombination and increased defect density. CeF?SA exhibited antimicrobial activity against Gram-positive (S. aureus, S. pneumoniae), Gram-negative (K. pneumoniae, E. coli), and the fungal pathogen C. albicans, with reduced MIC (650g/mL) and MBC (1050g/mL) against K. pneumoniae. SEM revealed pronounced bacterial membrane damage. In vitro MTT assays on L929 fibroblasts demonstrated > 80% cell viability at concentrations up to 60g/mL, indicating the nanoparticles are well-tolerated at sub-antimicrobial doses. Overall, CeF?SA represents a promising antimicrobial nanoplatform, with further studies needed to assess cytocompatibility at MIC-level concentrations. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026.
Source
Journal of Inorganic and Organometallic Polymers and Materials;
Date
01-01-2026
Publisher
Springer
Subject
Antimicrobial activity; CeF? nanoparticles; Cytocompatibility; Sodium alginate; Surface functionalization
Coverage
Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Ganeshkumar P., Department of Computer Science, College of Computer and Information Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Saudagar A.K.J., Information Systems Department, College of Computer and Information Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 15741443;
Format
online
Language
English
Type
Article

Citation

Thangavelu, Indumathi; Ganeshkumar, P.; Saudagar, Abdul Khader Jilani, “Sodium Alginate Coated Cerium(III) Fluoride Nanoparticles for Biocompatible Antimicrobial Applications: Structural and Functional Insights,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 19, 2026, https://archives.christuniversity.in/items/show/21916.

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