Sodium AlginateEngineered CaF? NPs: Surface Passivation, and Tunable Biofunctional Performance

Title

Sodium AlginateEngineered CaF? NPs: Surface Passivation, and Tunable Biofunctional Performance

Creator

Pachiyannan, Prabu; Thangavelu, Indumathi

Description

The optimization of surface chemistry in nanomaterials is vital for enhancing their applicability in advanced healthcare sectors. This study focuses on synthesizing polymer-functionalized NPs (NPs) to improve structural stability and biological efficacy against a broad spectrum of pathogens. Herein, calcium fluoride (CaF?) and sodium alginate-functionalized CaF? (CaF?SA) NPs were synthesized to determine the impact of SA on physicochemical and optical properties. The synthesized NPs were extensively characterized using XRD, UV-Vis, DLS, FTIR, PL, electron microscopy (SEM/TEM), and XPS. Their enhanced performance is attributed to defect passivation, reduced crystallite size, and the formation of a homogeneous organic-inorganic interface through strong chemical interactions between Ca? sites and alginate functional groups. The CaF?SA NPs exhibited superior broad-spectrum antimicrobial activity compared to bare CaF? against S. aureus, S. pneumoniae (Gram-positive), K. pneumoniae, E. coli (Gram-negative) and C. albicans (fungal strains). The quantitative assessments via MIC, MBC, and CFU assays confirmed effective inhibition of CaF2-SA. These findings highlight defect modulation and polymer passivation as powerful strategies, suggesting CaF?SA NPs as promising candidates for advanced bio-interactive and healthcare applications. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026.

Source

Journal of Inorganic and Organometallic Polymers and Materials;

Date

01-01-2026

Publisher

Springer

Subject

Antimicrobial activity; Bio-interactive; CaF?; CaF?SA; Fungal strains

Coverage

Pachiyannan P., Information Systems Department, College of Computer and Information Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India

Rights

Restricted Access; Hardcopy may be available in the library

Relation

ISSN: 15741443;

Format

online

Language

English

Type

Article

Identifier

https://doi.org/10.1007/s10904-026-04288-8

https://www.scopus.com/pages/publications/105035335384?origin=resultslist