Multifunctional Evaluation of CaCO3Sodium Alginate Nanocomposite for Antibacterial, Antifungal, and Anticancer Applications
- Title
- Multifunctional Evaluation of CaCO3Sodium Alginate Nanocomposite for Antibacterial, Antifungal, and Anticancer Applications
- Creator
- Thangavelu, Indumathi; Tadepalli, Srinivas; Gadallah, Abdelrahman G.
- Description
- In this study, Calcium carbonate (CaCO?) nanoparticles and calcium carbonatesodium alginate (CaCO?SA) nanocomposite were successfully synthesized via a controlled precipitation method and evaluated for multifunctional biomedical applications. Structural and surface analyses confirmed the formation of a calcite phase with effective surface functionalization using SA. The nanocomposite exhibited reduced crystallite size (~ 29nm vs. ~38nm for CaCO?), improved dispersion, and enhanced defect density, as evidenced by XRD, DLS, PL, and TEM analyses. PL studies revealed multiple defect-related emission bands (370534nm), indicating the presence of active surface states. The CaCO?SA nanocomposite demonstrated significantly enhanced antimicrobial activity compared to CaCO?, with zone of inhibition values reaching ~ 20mm (S. aureus), ~ 21mm (S. pneumoniae), ~ 20mm (E. coli), and ~ 18mm (C. albicans), comparable to standard drugs. CFU analysis confirmed a concentration-dependent reduction in bacterial viability, while MIC and MBC values were reduced to 500g mL? and 750g mL?, respectively, indicating improved bacteriostatic and bactericidal efficiency. In anticancer studies, the nanocomposite exhibited enhanced cytotoxicity against MG-63 osteosarcoma cells, reducing cell viability to ~ 30% at higher concentrations, while maintaining high biocompatibility of > 80% viability toward L929 fibroblast cells. Overall, this work highlights the potential of surface engineered CaCO? based nanomaterials as promising candidates for combined antimicrobial and anticancer applications, providing a foundation for future in-depth biological investigations and translational studies. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026.
- Source
- Journal of Inorganic and Organometallic Polymers and Materials;
- Date
- 01-01-2026
- Publisher
- Springer
- Subject
- Anticancer activity; Antimicrobial activity; CaCO3 nanoparticles; Nanocomposite; SA
- Coverage
- Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Gadallah A.G., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia
- Rights
- Restricted Access; Hardcopy may be available in the library
- Relation
- ISSN: 15741443;
- Format
- online
- Language
- English
- Type
- Article
Collection
Citation
Thangavelu, Indumathi; Tadepalli, Srinivas; Gadallah, Abdelrahman G., “Multifunctional Evaluation of CaCO3Sodium Alginate Nanocomposite for Antibacterial, Antifungal, and Anticancer Applications,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 19, 2026, https://archives.christuniversity.in/items/show/21918.