ItemArticle

Chitosan Coated-Liposomal Microencapsulation of Fucoidan Extracted from Marine Sargassum wightii: Assessment of Its Biofunctional and Therapeutic Properties

Title
Chitosan Coated-Liposomal Microencapsulation of Fucoidan Extracted from Marine Sargassum wightii: Assessment of Its Biofunctional and Therapeutic Properties
Creator
Mathew, Gicy; Amruth, P.
Description
Fucoidan, a sulphated polysaccharide derived from Sargassum wightii, holds significant therapeutic potential due to its antioxidant, antimicrobial, and wound-healing properties. Despite its therapeutic properties, its clinical efficacy is limited by poor bioavailability and instability. This study reports the successful encapsulation of fucoidan in liposomes employing the thin-film hydration technique, followed by chitosan coating to enhance its stability and biological activity. Structural integrity and successful encapsulation were confirmed through FTIR and UVVis spectroscopy. Antioxidant activity assessed via DPPH and hydrogen peroxide scavenging assays demonstrated concentration-dependent radical scavenging, with chitosan-coated formulations exhibiting superior efficacy. The formulation was reported to exhibit strong antioxidant potential, as indicated by DPPH (38.65% at 500?g/ml) and H?O? (40.707% at 400 ?g/ml). Antimicrobial testing revealed notable activity against the Gram-negative bacterium Escherichia coli, but not against the Gram-positive bacterium Bacillus subtilis, suggesting a narrow-spectrum antibacterial potential. The antimicrobial assays conducted reported a zone of inhibition of 11.4mm for a concentration of 2mg/ml. Furthermore, scratch wound assays and MTT-based cytotoxicity analysis on L929 fibroblast cells indicated promising wound-healing activity, with a wound closure of 92.72% observed 72h after treatment with the sample. The IC?? value of 100?g/ml was also reported to have high cell viability of 84.22%. These findings underscore the potential of chitosan-coated liposomal fucoidan as a multifunctional bioactive system for pharmaceutical and biomedical applications. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026.
Source
BioNanoScience;Volume;16;Issue;5;Article No.;340;
Date
01-01-2026
Publisher
Springer
Subject
Antioxidant; Chitosan; Cytotoxicity; Fucoidan; Micro-encapsulation; Mouse L929 fibroblast; Sargassum wightii; Wound-healing
Coverage
Mathew G., Department of Life Sciences, Christ University, Bangalore, 560029, India; Amruth P., Department of Life Sciences, Christ University, Bangalore, 560029, India, Centre for Landscapes, Wildlife and Marine Ecology (CLIME), Christ University, Bangalore, 560029, India
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 21911630;
Format
online
Language
English
Type
Article

Citation

Mathew, Gicy; Amruth, P., “Chitosan Coated-Liposomal Microencapsulation of Fucoidan Extracted from Marine Sargassum wightii: Assessment of Its Biofunctional and Therapeutic Properties,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 19, 2026, https://archives.christuniversity.in/items/show/22022.

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