ItemArticle

Synthesis and Biological Evaluation of Sr and Co Co-Doped TiO?Folic Acid Nanocomposites: Antibacterial, Antifungal (Candida albicans), Antioxidant (DPPH and Trolox), and In Vitro Anticancer Activity against HepG2 Cells

Title
Synthesis and Biological Evaluation of Sr and Co Co-Doped TiO?Folic Acid Nanocomposites: Antibacterial, Antifungal (Candida albicans), Antioxidant (DPPH and Trolox), and In Vitro Anticancer Activity against HepG2 Cells
Creator
Goyal, Prakhar; Ballal, Suhas; Saini, Ramesh; Awasthi, Kumud Kant; Dhingra, Lovish; Pund, Sachin S.; Thangavelu, Indumathi; Tadepalli, Srinivas
Description
Liver cancer and multidrug-resistant bacterial infections pose significant health challenges, highlighting the urgent need for multifunctional therapeutics. In this study, a TiO? nanocomposite co-doped with strontium (Sr) and cobalt (Co) and surface-functionalized with folic acid (TiO?SrCoFA) nanocomposite was synthesized via a hydrothermal method followed by post-synthesis FA functionalization. XRD confirmed the anatase phase, with reduced crystallite size for TiO?SrCoFA, while TEM showed spherical, uniformly dispersed nanoparticles (~ 23nm) with no agglomeration. DLS revealed a hydrodynamic diameter of 138.6nm, and XPS/FTIR confirmed Sr, Co, and FA incorporation. Optical studies (UV-Vis and PL) indicated electronic modifications conducive to ROS generation. TiO?SrCoFA exhibited enhanced antimicrobial activity against Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, Bacillus megaterium), Gram-negative bacteria (Klebsiella pneumoniae, Proteus vulgaris), and Candida albicans. Antioxidant assays demonstrated concentration-dependent scavenging (2883%) comparable to vitamin C. In HepG2 liver cancer cells, TiO?SrCoFA showed superior cytotoxicity with an IC?? of 6.5g/mL versus 9.8g/mL for TiO?, inducing apoptosis and oxidative stress. The enhanced bioactivity is attributed to nanoscale size, Sr/Co doping, FA-mediated targeting, and ROS generation. TiO?SrCoFA thus represents a promising multifunctional nanotherapeutic platform for simultaneous antimicrobial, antioxidant, and anticancer applications. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026.
Source
BioNanoScience;Volume;16;Issue;5;Article No.;322;
Date
01-01-2026
Publisher
Springer
Subject
Folic acid functionalisation; Hydrothermal synthesis; Liver cancer HePG-2 cells; Sr and Co co-doped; TiO?SrCoFA
Coverage
Goyal P., Quantum University Research Center, Quantum University, Uttarakhand, Roorkee, 247667, India; Ballal S., Department of Chemistry and Biochemistry, JAIN (Deemed-to-be University), Karnataka, Bangalore, 560002, India; Saini R., Centre of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, 140417, India; Awasthi K.K., Department of Sciences, Vivekananda Global University, Jaipur, 303012, India; Dhingra L., Chitkara Centre for Research and Development, Chitkara University, Himachal Pradesh, 174103, India; Pund S.S., Department of Industrial Engineering, Shri Ramdeobaba College of Engineering and Management, Maharashtra, Nagpur, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 21911630;
Format
online
Language
English
Type
Article

Citation

Goyal, Prakhar; Ballal, Suhas; Saini, Ramesh; Awasthi, Kumud Kant; Dhingra, Lovish; Pund, Sachin S.; Thangavelu, Indumathi; Tadepalli, Srinivas, “Synthesis and Biological Evaluation of Sr and Co Co-Doped TiO?Folic Acid Nanocomposites: Antibacterial, Antifungal (Candida albicans), Antioxidant (DPPH and Trolox), and In Vitro Anticancer Activity against HepG2 Cells,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 20, 2026, https://archives.christuniversity.in/items/show/22021.

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