ItemArticle

Green synthesis of biocompatible L-Histidine-Modified NiFe2O4 Nanoparticles: A multifaceted approach toward cancer and bacterial therapy

Title
Green synthesis of biocompatible L-Histidine-Modified NiFe2O4 Nanoparticles: A multifaceted approach toward cancer and bacterial therapy
Creator
Thangavelu, Indumathi; Tadepalli, Srinivas; Kasibatla, Murthy S.
Description
Cancer and infections caused by microbes remain serious global health threats, with multidrug resistance and toxicity associated with treatment constraining the efficacy of traditional therapies. In the present research, biocompatible L-histidine-functionalized nickel ferrite nanoparticles (NiFe2O4-LH) were green synthesized using of Clitoria ternatea flower extract and systematically evaluated for their therapeutic effects. Characterization established their spinel cubic structure, reduced crystallite size (14.4 nm), and enhanced stability when compared to bare NiFe2O4 (21.6 nm). UVvisible spectra revealed a blue shift with expanded band gap from 3.16 eV (NiFe2O4) to 3.92 eV (NiFe2O4-LH). The PL spectra revealed that the NiFe2O4-LH exhibited green emission at 516, 526 nm suggesting increased oxygen vacancies facilitating ROS production. The NiFe2O4-LH NPs demonstrated excellent antibacterial activity when compared to pure NiFe2O4. SEM analysis confirmed extensive bacterial membrane breakdown when exposed to NiFe2O4-LH. Cytotoxicity to MDA-MB-231 breast cancer cells showed a significant dose-dependent response with an IC50 of 12.41 ?g/mL. Biocompatibility assessments with zebrafish embryos supported negligible development toxicity, wherein NiFe?O?-LH-treated groups preserved normal morphology until 72 hpf compared to the bare NiFe2O4. 2025 Elsevier B.V.
Source
Journal of Molecular Structure;Volume;1352;Issue;;Article No.;144396;
Date
01-01-2026
Publisher
Elsevier B.V.
Subject
Antibacterial activity; Anticancer activity; Biocompatibility; L-histidine functionalization; MDA-MB-231; NiFe2O4; Zebrafish embryo
Coverage
Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Kasibatla M.S., Department of Chemistry, Applied Science Cluster, University of Petroleum and Energy Studies, Uttarakhand, Dehradun, 248007, India
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 222860; CODEN: JMOSB
Format
online
Language
English
Type
Article

Citation

Thangavelu, Indumathi; Tadepalli, Srinivas; Kasibatla, Murthy S., “Green synthesis of biocompatible L-Histidine-Modified NiFe2O4 Nanoparticles: A multifaceted approach toward cancer and bacterial therapy,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22407.

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