ItemArticle

Biofunctional NiTiO3D-carvone nanocomposite: Synthesis, characterization, antibacterial, antioxidant, and zebrafish biocompatibility evaluation

Title
Biofunctional NiTiO3D-carvone nanocomposite: Synthesis, characterization, antibacterial, antioxidant, and zebrafish biocompatibility evaluation
Creator
Thangavelu, Indumathi; Tadepalli, Srinivas; Kasibatla, Murthy S.
Description
The growing threat of microbial resistance and oxidative stress-related disorders highly demands the development of multifunctional nanoparticles with enhanced bioactivity and biocompatibility. In response to this demand, D-carvone functionalized nickel titanate (NiTiO?-D-carvone) was synthesized. XRD confirmed the formation of a crystalline rhombohedral NiTiO3 phase, while HRTEM revealed reduced agglomeration and uniform distribution upon D-carvone modification. The average crystallite size of the composite was 27 nm. DLS analysis showed a decreased hydrodynamic diameter (D?? = 112.50 nm) for the functionalized nanocomposite compared to bare NiTiO3 (225.70 nm). XPS spectra confirmed the presence of Ni? and Ti?? oxidation states, along with C=O and CO groups from D-carvone. The NiTiO3D-carvone nanocomposite exhibited a surface area of 2.658 m/g and showed strong UV absorption at 326 nm. PL studies revealed that the nanocomposite exhibited green emission at 524 nm, attributed to oxygen vacancy-related defect states which is favorable for enhanced ROS generation. Antibacterial studies demonstrated enhanced inhibition zones against K. pneumoniae (16 mm), S. dysenteriae (17 mm), Escherichia coli (18 mm) P. aeruginosa (12 mm) and P. vulgaris (17 mm) compared to bare NiTiO?. CFU assays revealed a concentration-dependent reduction in viable colonies, with the highest activity at 10 mg/mL. The antioxidant efficiency reached 61.4 % DPPH inhibition at 20 g/mL, closely comparable to Vitamin C (64.7 %). Zebrafish embryo assays confirmed excellent biocompatibility of the NiTiO?D-carvone system, with normal morphology and survival up to 96 hpf. The experimental results suggest that surface modification with D-carvone significantly enhances the biological activity and safety of NiTiO3 nanoparticles. 2025
Source
Journal of Molecular Structure;Volume;1354;Issue;;Article No.;144872;
Date
01-01-2026
Publisher
Elsevier B.V.
Subject
Antibacterial activity; Antioxidant assay; Biocompatibility; D-carvone; Nickel titanate; Zebrafish embryo
Coverage
Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Kasibatla M.S., Department of Chemistry, Applied Science Cluster, University of Petroleum and Energy Studies, Uttarakhand, Dehradun, 248007, India
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 222860; CODEN: JMOSB
Format
online
Language
English
Type
Article

Citation

Thangavelu, Indumathi; Tadepalli, Srinivas; Kasibatla, Murthy S., “Biofunctional NiTiO3D-carvone nanocomposite: Synthesis, characterization, antibacterial, antioxidant, and zebrafish biocompatibility evaluation,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22408.

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