ItemArticle

Advanced electrochemical detection and profiling of the antihypertensive drug atenolol via a SPION-activated carbon nanocomposite interface

Title
Advanced electrochemical detection and profiling of the antihypertensive drug atenolol via a SPION-activated carbon nanocomposite interface
Creator
Agnihotri, Ananya S.; Nidhin, M.
Description
This study reports the synthesis of superparamagnetic iron oxide nanoparticles (SPIONs), activated carbon (AC) and SPION-AC nanocomposites using a simple hydrothermal method. Characterization of the synthesized materials includes dynamic light scattering, X-ray diffraction, field emission scanning electron microscopy, high resolution transmission electron microscopy, and vibrating sample magnetometry, along with electrochemical characterization studies such as electrochemical impedance spectroscopy. Among the SPION-AC nanocomposites, SPION-15%AC was employed to modify a glassy carbon electrode (GCE). The synergistic interaction between SPION and AC significantly enhanced the electrochemical properties of the system, leading to the development of a highly efficient platform for the detection of the antihypertensive drug atenolol (ATN) in commercial tablet samples. The sensor demonstrated excellent performance, with a linear detection range from 1.21 ?M to 285 ?M. With a low detection limit (LOD) of 0.401 ?M, the sensor offers precise quantification of ATN, making it a promising tool for improving patient care. High selectivity, reproducibility, and excellent recovery in complex pharmaceutical matrices further highlight the potential of this sensor for biomedical and clinical applications. 2025 RSC.
Source
Nanoscale Advances;Volume;7;Issue;14;pp.4397-4411
Date
01-01-2025
Publisher
Royal Society of Chemistry
Coverage
Agnihotri A.S., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India; Nidhin M., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India
Rights
All Open Access; Gold Open Access; Green Open Access
Relation
ISSN: 25160230;
Format
online
Language
English
Type
Article

Citation

Agnihotri, Ananya S.; Nidhin, M., “Advanced electrochemical detection and profiling of the antihypertensive drug atenolol via a SPION-activated carbon nanocomposite interface,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22562.

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