ItemArticle

Phytofabricated Silver Nanoparticles Derived from Leea crispa Leaf Extract: Antituberculosis and Anticancer Activities

Title
Phytofabricated Silver Nanoparticles Derived from Leea crispa Leaf Extract: Antituberculosis and Anticancer Activities
Creator
Doddamani, Tejshwini; Balasubramanian, Balamuralikrishnan; Kakkalameli, Siddappa; Sebastian, Joseph Kadanthottu; Pappuswamy, Manikantan; Almutairi, Bader O.; Almutairi, Mikhlid H.; Daphedar, Azharuddin
Description
Aqueous extracts of Leea crispa used for producing silver nanoparticles (AgNPs) with the supplementation of the external capping substance, were determined by UV-Visible spectroscopy. The synthesized nanoparticles were examined for their antituberculosis and anticancer activities. The presence of phytoconstituents available for reducing silver ions and to form the AgNPs was confirmed using FTIR analysis. The XRD and TEM examination validated the AgNPs spherical particle shape and size of 15 to 85 nm and their face-centered cubic crystal form. Additionally, the FTIR spectrum revealed variation in the band values in the range 1384.0 to 3419.4 cm-1, respectively, and the EDX noted a strong band at 3 keV induced the presence of metallic silver. The AgNPs exhibited comparatively potential anti-tuberculosis activity (0.2 to 100 g/mL) respectively. Alternatively, various doses of AgNPs, 12.5 to 400 g/mL documented considerable activity towards the human breast cancer cell lines. The percentage of cell viability increased at 12.5g/mL and declined at 400 ng/mL concentrations of AgNPs solution. The AgNPs synthesized from L. crispa exhibited potential activity against life-threatening tuberculosis and cancer cells. 2025, North Carolina State University. All rights reserved.
Source
BioResources ;Volume;20;Issue;1;pp.452-464
Date
01-01-2025
Publisher
North Carolina State University
Subject
AgNO3; Anti-cancer; Anti-tuberculosis; Leea crispa; MCF-7 Cell line; MTT Assay; TEM
Coverage
Doddamani T., Department of Botany, Environmental Biology Laboratory, Karnatak University, Karnataka, Dharwad, 580 003, India; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Kakkalameli S., Department of Botany, Environmental Biology Laboratory, Davangere University, Karnataka, Davangere, 577002, India; Sebastian J.K., Department of Life Sciences, Christ University, Karnataka, Bengaluru, 560029, India; Pappuswamy M., Department of Life Sciences, Christ University, Karnataka, Bengaluru, 560029, India; Almutairi B.O., Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia; Almutairi M.H., Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia; Daphedar A., Department of Botany, Environmental Biology Laboratory, Karnatak University, Karnataka, Dharwad, 580 003, India, Department of Botany, Anjuman Arts, Science and Commerce College, Karnataka, Vijayapur, 586 101, India
Rights
All Open Access; Gold Open Access; Green Open Access
Relation
ISSN: 19302126;
Format
online
Language
English
Type
Article

Citation

Doddamani, Tejshwini; Balasubramanian, Balamuralikrishnan; Kakkalameli, Siddappa; Sebastian, Joseph Kadanthottu; Pappuswamy, Manikantan; Almutairi, Bader O.; Almutairi, Mikhlid H.; Daphedar, Azharuddin, “Phytofabricated Silver Nanoparticles Derived from Leea crispa Leaf Extract: Antituberculosis and Anticancer Activities,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/23333.

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