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Heteroatom doped coke based nanocarbon for the detection of oxytocin /
Patent Number: 202141052664, Applicant: Riya Thomas.
The present invention provides a facile, scalable, and cost-effective method for preparing heteroatom doped nanocarbon extracted from coke that possesses an excellent electrochemical activity. The synthesized nanostructure modified electrode is used for the rapid quantitative detection of Oxytocin in the range of 0.1 to 95 nM with a limit of detection of 40 pM. -
Heteroatom engineered graphene-based electrochemical assay for the quantification of high-risk abused drug oxytocin in edibles and biological samples
The naive detection of scheduled H drug oxytocin is a vital requisite, owing to its deleterious impact on societal affluence prompted by unconstrained usage. Therefore, a reliable, cost-effective, and quick-to-respond analytic technique for this drug is in ample demand. In this work, we report electrochemical detection of oxytocin employing novel nitrogen, phosphorus co-doped coke-derived graphene (NPG) modified electrode. The electro-oxidation behavior of oxytocin was investigated on the NPG modified electrode by square wave stripping voltammetry (SWSV) in 0.1 M phosphate buffer of pH 7. The oxidation peak current was linear in two ranges, spanning from 0.1 nM to 10 nM and 15 nM to 95 nM. The limit of detection at the NPG electrode was calculated to be 40 pM. The practical application of developed sensor for the determination of oxytocin was examined in edible products and body fluids, hence signifying the possibility of having real-time surveillance over its misusage. 2022 Elsevier Ltd -
Heterocyclic compounds and uses thereof /
Patent Number: US20190106436, Applicant: NUVATION BIO INC.
Heterocyclic compounds as Weel inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology. -
Heterogeneous Catalysis in the Synthesis of Nitrogen-Containing Heterocyclics
The synthesis of nitrogen-containing heterocyclic compounds using heterogeneous catalysis is a topic of significant interest in organic synthesis and chemical research. Heterogeneous catalysis offers several advantages over homogeneous catalysis, including easier separation and recovery of the catalyst, reduced waste generation, and potentially higher stability and reusability. In this review, the pivotal role of heterogeneous catalysis in synthesizing nitrogen-containing heterocyclic compounds is explored. Various types of heterocycles and the specific applications of these compounds in drug discovery and material development are discussed in detail. This review discusses various examples of heterogeneous catalysts employed in the synthesis of nitrogen-containing heterocycles, including metal oxides, supported metals, metal nanoparticles, zeolites, and other porous materials. Emphasis is placed on the mechanistic insights and reaction pathways facilitated by different catalysts. Additionally, recent advancements and innovations in the field are discussed, including novel catalyst designs, green chemistry approaches, and emerging trends in catalytic materials. The aim is to provide a comprehensive overview of the impact and potential of heterogeneous catalysis in this important area of organic synthesis. 2024 Wiley-VCH GmbH. -
Heterojunction engineered MWCNT/Ag3PO4 via organic acid and its natural light-assisted photocatalytic efficiency
Compositing photoactive, but unstable semiconductors with low dimensional carbon-based materials and modulating the hetero junction between them can assure more efficient and stable systems for the remediation of severe pollutants. The current study has given emphasis to understand the role of sulfonic acid in making a compact heterojunction between AP and MWCNTs, considering the effective delocalization of carriers and the direct relationship with the photoactivity. The significant reduction in the band gap of AP from 2.320 to 2.0516ev after the introduction of MWCNTs unmistakably confirmed the compatibility between the composite moieties. The intensity of the photoluminescence peak observed at an emission wavelength of 350nm for pure AP was found to be minimized in the composite, which confirms the effective charge delocalization from AP to the conductive MWCNTs. The closest bond distance was observed in the range of 2.3 to 2.5between an O atom of Ag3PO4 and a C atom of CNT, which explains the tight contact between the species. The photoactivity studies unambiguously confirmed the potential of the organic acid at the composite interface as it could accomplish 99% dye degradation within a span of 8min, whilst the system without the organic acid exhibited complete degradation within a span of 60min. The p-XRD analysis of the catalyst recovered from the reaction mixture revealed its high stability. 2023 Elsevier B.V. -
Heuristic and biases related to finanical investment and the role of behavioral finance in investment decisions - A study /
Zenith International Journal Of Business Economics And Management Research, Vol.5, Issue 12, pp. -
HHO-Based Vector Quantization Technique for Biomedical Image Compression in Cloud Computing
In the present digital era, the exploitation of medical technologies and massive generation of medical data using different imaging modalities, adequate storage, management, and transmission of biomedical images necessitate image compression techniques. Vector quantization (VQ) is an effective image compression approach, and the widely employed VQ technique is Linde-Buzo-Gray (LBG), which generates local optimum codebooks for image compression. The codebook construction is treated as an optimization issue solved with utilization of metaheuristic optimization techniques. In this view, this paper designs an effective biomedical image compression technique in the cloud computing (CC) environment using Harris Hawks Optimization (HHO)-based LBG techniques. The HHO-LBG algorithm achieves a smooth transition among exploration as well as exploitation. To investigate the better performance of the HHO-LBG technique, an extensive set of simulations was carried out on benchmark biomedical images. The proposed HHO-LBG technique has accomplished promising results in terms of compression performance and reconstructed image quality. 2023 World Scientific Publishing Company. -
Hi line analysis of Herbig Ae/Be stars using X-Shooter spectra
Herbig Ae/Be stars are intermediate-mass pre-main sequence stars undergoing accretion through their circumstellar disk. The optical and infrared (IR) spectra of HAeBe stars show Hi emission lines belonging to Balmer, Paschen and Brackett series. We used the archival X-Shooter spectra available for 109 HAeBe stars from Vioque et al. (2018) and analysed the various Hi lines present in them. We segregated the stars into different classes based on the presence of higher-order lines in different Hi series. We discussed the dependence of the appearance of higher-order lines on the stellar parameters. We found that most massive and younger stars show all the higher-order lines in emission. The stars showing only lower-order lines have Teff< 12 , 000 K and an age range of 510 Myr. We performed a case B line ratio analysis for a sub-sample of stars showing most of the Hi lines in emission. We noted that all but four stars belonging to the sub-sample show lower Hi line ratios than theoretical values, owing to the emitting medium being optically thick. The Hiline flux ratios do not depend on the stars spectral type. Further, from the line ratios of lower-order lines and Paschen higher-order lines, we note that line ratios of most HAeBe stars match with electron density value in the range of 10 9 10 11 cm - 3 . The electron temperature, however, could not be ascertained with confidence using the line ratios studied in this work. 2023, Indian Academy of Sciences. -
Hidden Markov Model: Application towards genomic analysis
Hidden Markov Model (HMM) has become one of the interesting methods for the researchers, especially in bioinformatics where different analysis are carried out. These are widely used in science, engineering and many other areas such as bioinformatics, genomic mapping, computer vision, finance and economics, and in social science. HMMs require much smaller training sets, and that the examination of the inner structure of the model provides often a deeper understanding of the phenomenon. In this survey, we first describe the important algorithms for the HMMs, and provide useful comparisons, aiming at their advantages and shortcomings. We then consider the major g applications, such as annotations, gene alignment and profiling of sequences, DNA structure prediction, and pattern recognition. We also list some analysis on how to use HMM for DNA genomes. Finally, we conclude use and perspectives of HMMs in bioinformatics and provide a critical appraisal for the same. 2016 IEEE. -
Hierarchical BiFeO3/Cr2CTx MXene composite as a multifunctional catalyst for hydrogen evolution reaction and as an electrode material for energy storage devices
A multifunctional hierarchical Bismuth ferrite/chromium carbide (BiFeO3/Cr2CTx) MXene has been employed as both electrode material for supercapacitors as well as an electrocatalyst for electrocatalytic water splitting. Here, a facile method is suggested for synthesizing Cr2CTx MXene from the chromium aluminum carbide (Cr2AlC) MAX Phase. X-ray diffraction studies, Scanning electron microscopy, and high-resolution transmission electron microscopy indicate that the aluminum atomic layers are removed from Cr2AlC MAX structure. The electrochemical test reveals that the BiFeO3/Cr2CTx MXene composite, which is produced with less Al2O3, performs well in the hydrogen evolution reaction (HER) with a low overpotential of 128 mV in 1 M potassium hydroxide. 53.3 mV dec?1, and 0.16 ? cm?2, respectively, are the values of the calculated Tafel slope and charge transfer resistance. In a dielectrode electrolysis system, BiFeO3/Cr2CTx MXene electrode needs only 1.81 V of cell potential to provide 10 mA cm?2 with long-term stability. The specific capacity of 671.2 C g?1 at a current density of 1 A g?1 is obtained for BiFeO3/Cr2CTx MXene electrode with 90% capacitance retention after 3000 cycles. The potential use of BiFeO3/Cr2CTx MXene towards HER and supercapacitor application is demonstrated by this study, which offers a gentle path for the fabrication of Cr2CTx MXene composites for energy storage and HER applications. 2023 Elsevier Ltd -
Hierarchical porous covalent organic framework-based sensor for the detection of neurodegenerative disorder biomarkers
Guanosine is an essential biomarker that enacts an important role in neuroprotection against brain-related activities, influences the metabolism of fatty acids, and assists in the improvement of the gastrointestinal tract. A facile and selective electrochemical sensor has been developed for the sensing of guanosine based on a hierarchical porous covalent organic framework. Owing to the distinctive 2D porous architecture and ordered framework of TpBD-COF, the irreversible electrooxidation of guanosine occurred at 1.03 V (vs. SCE) in phosphate buffer solution at pH 6. The anodic peak currents under optimal conditions were linear with guanosine concentration within the range of 0.123720 ?M with a LOD of 40.63 nM under various optimal conditions. Moreover, the developed biosensor was used to determine guanosine in pharmaceutical tablets to confirm its potential application in the healthcare industry. 2023 Elsevier B.V. -
Hierarchically nanostructured ZnO with enhanced photocatalytic activity
Hierarchical nanostructures of ZnO are integrated architectures comprising well-ordered nanoscale subunits and excellent photocatalytic properties. In this study, synthesis of ZnO nanoparticles using methods such as co-precipitation, hydrothermal, thermal decomposition, and electrochemical precipitation yielded microsphere, nanorod, pyramid, and nanopetal-like morphologies, respectively. The catalysts obtained were characterized using XRD, IR, SEM-EDX, UVDRS, TGA, PL, and Zeta potential analysis. The XRD spectra confirmed that all the different morphologies of ZnO have hexagonal wurtzite structures The photocatalytic activity of these nanostructures was determined using a dye degradation study on a model pollutant Methylene Blue (MB) under simulated visible light. The kinetic study of the dye degradation reveals that it obeys pseudo-first-order kinetics with a maximum rate constant of 0.01503 min-1. The nanorod structured ZnO particles prepared by the hydrothermal method showed the best catalytic activity. 2021 The Electrochemical Society ("ECS"). Published on behalf of ECS by IOP Publishing Limited. -
Hierarchically porous MN-MOFS composite with RGO as an efficient electrode material for supercapacitor application /
Patent Number: 202241046378, Applicant: Sruthi Rajasekaran.
The present invention shows the energy storage application of the manganese-reduced graphene oxide metal organic frameworks (Mn-rGO MOFs) using the ligand, pyridine 2,6 dicarboxylic acid (PDA), under mild conditions. The methodology followed was hydrothermai at 160°C with manganese sulfate as metal salt, rGO along with the PDA ligand in pyridine, and water as solvent. The development of efficient Mn-rGO MOFs is suitable for supercapacitance energy storage applications, which is the future need for various industrial applications. -
Hierarchically porous MN-MOFS composite with RGO as an efficient electrode material for supercapacitor application /
Patent Number: 202241046378, Applicant: Sruthi Rajasekaran.
The present invention shows the energy storage application of the manganese-reduced graphene oxide metal organic frameworks (Mn-rGO MOFs) using the ligand, pyridine 2,6 dicarboxylic acid (PDA), under mild conditions. The methodology followed was hydrothermai at 160°C with manganese sulfate as metal salt, rGO along with the PDA ligand in pyridine, and water as solvent. The development of efficient Mn-rGO MOFs is suitable for supercapacitance energy storage applications, which is the future need for various industrial applications. -
High Gain Miniature Antenna Arrays for 2.4 GHz Applications
In this paper, miniature corporate feed Four Element Array (FEA), Eight Element Array (EEA) and Sixteen Element Array (SEA) are presented. The proposed antenna arrays are created on Rogers Duroid 5880 substrate with permittivity 2.2 and thickness of 0.782 mm. Initially, a single element antenna was created, then it was used in a corporate feed network designed for the 4-element array. As an extension, the 4-element array was used as a template and created an 8-element array and 16-element array to achieve high gain and directivity at 2.4 GHz. The proposed FEA, EEA, and SEA exhibit reflection coefficients of -25.55 dB, -37.14 dB, and -30.61 dB respectively. The peak gains obtained are 11.5 dB, 13.67 dB, and 16.76 dB respectively for FEA, EEA, and SEA. Also, the directivity has improved corresponding to the increase in the number of elements. Therefore, it can be a suitable candidate for applicationswhere extended range and coverage with better signal quality and higher data transfer rates is a priority. 2024 IEEE. -
High gain ultra wideband fractal antenna
A high gain Compact Octagonal Ultra-wideband Fractal Antenna (COUFA) using the Dual Layer Meta Frequency Selective Surface Reflector (DLMFSSR) is presented in this manuscript. The proposed Frequency Selective Surface (FSS) provides a suitable reflection phase to act as a reflector and is capable of enhancing the gain of the antenna in its wide operating bandwidth. The proposed antenna design provides better impedance bandwidth of 2-10.37 GHz with significant increase in the gain of 0.41-11.83 dB at various resonance frequencies in comparison with the antenna without reflector. The complete antenna with DLMFSSR is designed and simulated using High Frequency Structure Simulator (HFSS). The Proposed antenna, FSS are fabricated and the numerical results for return loss S11, VSWR and gain are demonstrated. Simulation and fabrication results are found to be worthy, which suites the design malleable enough for several modern UWB wireless applications. Copyright 2019 American Scientific Publishers All rights reserved. -
High performance computational method for fractional model of solid tumour invasion
The behaviour of the solid tumour invasion system in the sense of Caputo fractional with time ? and space x is analyzed by the high performance computational method: q-Homotopy Analysis Transform method (q-HATM). The existence of the solutions has been verified with the assist of fixed point theorem and derived numerical solution for different values of ?,?,h. The novel simulation for all cases is explained through figures. We derived that the method is very efficient for analyzing the behaviour of the epidemiological system. 2023 THE AUTHORS -
High surface area Nanoflakes of P-gC3N4 photocatalyst loaded with Ag nanoparticle with intraplanar and interplanar charge separation for environmental remediation
The photocatalytic performance of gC3N4 is majorly restricted by insufficient collection of photogenerated charges on the surface during reaction due to highly dense stacking of lamellar structures with lateral size ranging in microns. This deficiency can be overcome by forming thin nanoflakes by systematically breaking the weak bonds that hold the gC3N4 framework without destroying the basic heptazine unit. With this aim, herein, a combination of three different strategies was implemented to design and develop, Ag-loaded and P-doped gC3N4 nanoflakes (Ag3-P1-NF-gC3N4). Using a systematic synthesis method, bulk gC3N4 was first converted into thin nanosheets, followed by fragmentation into nanoflakes, with a planar size up to 100 nm. P doping to replace the corner C atoms in the gC3N4 matrix (forming P[sbnd]N bonds) and intercalation of plasmonic Ag nanoparticles within the interlayers also assists in the bifurcation of the stacked layers and formation of nanoflake morphology. These strategies result in a significant increase in BET surface area to ?196 m2/g from 12 m2/g of bulk gC3N4. Improved inter-planar and intra-planar charge mobility was recorded as a result of the reduced sizes. Doping with P also causes higher absorption of the visible spectrum in gC3N4 while the formation of heterojunction with Ag nanoparticles induces efficient separation of photo-generated charges. All these promoting photo-physical properties lead to an outstanding photocatalytic activity towards degradation of aqueous pollutants with reaction rates ?20 times higher than bulk gC3N4. Complete mineralization of the pollutant and formation of non-toxic byproducts was also confirmed with suitable chromatography techniques. 2020 Elsevier B.V. -
High-affinity binding of celastrol to monomeric ?-synuclein mitigates invitro aggregation
?-Synuclein (?Syn) aggregation is associated with Parkinsons disease (PD). The region ?Syn36-42 acts as the nucleation 'master controller and ?Syn1-12 as a secondary nucleation site. They drive monomeric ?Syn to aggregation. Small molecules targeting these motifs are promising for disease-modifying therapy. Using computational techniques, we screened thirty phytochemicals for ?Syn binding. The top three compounds were experimentally validated for their binding affinity. Amongst them, celastrol showed high binding affinity. NMR analysis confirmed stable ?Syn-celastrol interactions involving several residues in the N-terminus and NAC regions but not in the C-terminal tail. Importantly, celastrol interacted extensively with the key motifs that drive ?Syn aggregation. Thioflavin-T assay indicated that celastrol reduced ?Syn aggregation. Thus, celastrol holds promise as a potent drug candidate for PD. Communicated by Ramaswamy H. Sarma. 2023 Informa UK Limited, trading as Taylor & Francis Group. -
High-Movement Human Segmentation in Video Using Adaptive N-Frames Ensemble
A wide range of camera apps and online video conferencing services support the feature of changing the background in real-time for aesthetic, privacy, and security reasons. Numerous studies show that the Deep-Learning (DL) is a suitable option for human segmentation, and the ensemble of multiple DL-based segmentation models can improve the segmentation result. However, these approaches are not as effective when directly applied to the image segmentation in a video. This paper proposes an Adaptive N-Frames Ensemble (AFE) approach for high-movement human segmentation in a video using an ensemble of multiple DL models. In contrast to an ensemble, which executes multiple DL models simultaneously for every single video frame, the proposed AFE approach executes only a single DL model upon a current video frame. It combines the segmentation outputs of previous frames for the final segmentation output when the frame difference is less than a particular threshold. Our method employs the idea of the N-Frames Ensemble (NFE) method, which uses the ensemble of the image segmentation of a current video frame and previous video frames. However, NFE is not suitable for the segmentation of fast-moving objects in a video nor a video with low frame rates. The proposed AFE approach addresses the limitations of the NFE method. Our experiment uses three human segmentation models, namely Fully Convolutional Network (FCN), DeepLabv3, and Mediapipe. We evaluated our approach using 1711 videos of the TikTok50f dataset with a single-person view. The TikTok50f dataset is a reconstructed version of the publicly available TikTok dataset by cropping, resizing and dividing it into videos having 50 frames each. This paper compares the proposed AFE with single models and the Two-Models Ensemble, as well as the NFE models. The experiment results show that the proposed AFE is suitable for low-movement as well as high-movement human segmentation in a video. 2022 Tech Science Press. All rights reserved.