Synthesis, spectral and DNA/Protein binding evaluation of novel Cu(II) chelates of an NNO donor tridentate aroylhydrazone: Halogen bonding directed close packing
- Title
- Synthesis, spectral and DNA/Protein binding evaluation of novel Cu(II) chelates of an NNO donor tridentate aroylhydrazone: Halogen bonding directed close packing
- Creator
- Nair Y.S.; Venkataraman S.K.; Joy F.; Krishna P.M.; Agarwal A.K.; Vinod T.P.; Madathil P.K.; Kurup M.R.P.
- Description
- An NNO donor aroylhydrazone monohydrate, HFPBH2O (3-fluoropyridine-2-carbaldehyde benzoylhydrazone monohydrate) was synthesized from 3-fluoropyridine-2-carbaldehyde and benzhydrazide and physicochemically characterised. The coordination behaviour of the aroylhydrazone with the metal ion is investigated through various physicochemical techniques and it is concluded that it binds to the metal ion predominantly in the enolate resonance form, while few complexes exhibit keto form of the ligand. The structure of [Cu(FPB)(OAc)(H2O)]H2O (4a) established by single-crystal X-ray diffraction method unveiled that the metal ion has a distorted square-pyramidal geometry in this complex. The coordination sites of Cu(II) ion are occupied by azomethine N, pyridyl N and iminolate O from a monodeprotonated hydrazone moiety and the remaining two positions are occupied by two oxygen atoms, one each from acetate ion and the water molecule. Potential applications of the complexes were studied by subjecting them to DNA/protein (BSA) binding studies using electronic and fluorescence spectroscopy. The complexes were found to bind with DNA/protein (BSA) with binding constants in the order of 104 M?1 to 105 M?1. The intercalative mode of binding of the complexes with DNA was proved using spectral studies and molecular docking. Furthermore, the complex [Cu(FPB)(N3)(H2O)2] (5) was found to cleave the DNA from form I to form II during gel electrophoresis studies. 2020 Elsevier B.V.
- Source
- Journal of Molecular Structure, Vol-1217
- Date
- 2020-01-01
- Publisher
- Elsevier B.V.
- Subject
- Aroylhydrazone; Benzhydrazide; DNA/Protein binding; Gel electrophoresis; Halogen bonding; Molecular docking
- Coverage
- Nair Y.S., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, Karnataka, India; Venkataraman S.K., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, Karnataka, India; Joy F., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, Karnataka, India; Krishna P.M., Department of Chemistry, M. S. Ramaiah Institute of Technology, Bangalore, 560 054, India; Agarwal A.K., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, Karnataka, India; Vinod T.P., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, Karnataka, India; Madathil P.K., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bangalore, 560029, Karnataka, India; Kurup M.R.P., Department of Chemistry, School of Physical Sciences, Central University of Kerala, Tejaswini Hills, Periye, Kasaragod, 671 320, India
- Rights
- Restricted Access
- Relation
- ISSN: 222860; CODEN: JMOSB
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Nair Y.S.; Venkataraman S.K.; Joy F.; Krishna P.M.; Agarwal A.K.; Vinod T.P.; Madathil P.K.; Kurup M.R.P., “Synthesis, spectral and DNA/Protein binding evaluation of novel Cu(II) chelates of an NNO donor tridentate aroylhydrazone: Halogen bonding directed close packing,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/16223.