ItemArticle

Advancing precision medicine: Uncovering biomarkers and strategies to mitigate immune-related adverse events in immune checkpoint inhibitors therapy

Title
Advancing precision medicine: Uncovering biomarkers and strategies to mitigate immune-related adverse events in immune checkpoint inhibitors therapy
Creator
Nityashree, K.L.; Rachitha, P.; Hanchinmane, Shilpa; Raghavendra, Vinay B.
Description
Immune-related adverse events (irAEs) can have a major influence on patient outcomes, but their usage is frequently confounded by immune checkpoint inhibitors (ICIs), which have revolutionized cancer treatment by increasing anti-tumor immunity. With a focus on immunological dysregulation and the resulting tissue-specific toxicities, this review clarifies the fundamental processes of irAEs. We look at contemporary clinical treatment techniques to lessen the impact of these adverse events, such as the application of immunosuppressants and patient monitoring procedures. Additionally, it is emphasized how future research is necessary to find predictive biomarkers that can forecast the development of irAEs, allowing for early intervention and individualized therapy methods. In order to improve the therapeutic index of ICIs, we also examine the crucial balance between optimizing anti-tumor activity and reducing immunotoxicity. This study aims to further the existing discussion on enhancing the safety and effectiveness of ICI medicines, which will eventually improve cancer patient care, by pointing out possible research avenues. 2025 The Authors
Source
Toxicology Reports;Volume;14;Issue;;Article No.;102035;
Date
01-01-2025
Publisher
Elsevier Inc.
Subject
Biomarkers; Immuno-related adverse events; Immunosuppressants; Immunotherapy; Immunotoxicity; Precision medicine
Coverage
Nityashree K.L., Christ University, Department of Psychology, Bangalore, India; Rachitha P., PG Department of Biotechnology, Teresian College, Siddarthanagar, Mysuru, 570011, India; Hanchinmane S., PG Department of Biotechnology, Teresian College, Siddarthanagar, Mysuru, 570011, India; Raghavendra V.B., PG Department of Biological Sciences, Jyoti Nivas College, Autonomous Koramangala, Bengaluru, 560095, India
Rights
All Open Access; Gold Open Access; Green Open Access
Relation
ISSN: 22147500;
Format
online
Language
English
Type
Article

Citation

Nityashree, K.L.; Rachitha, P.; Hanchinmane, Shilpa; Raghavendra, Vinay B., “Advancing precision medicine: Uncovering biomarkers and strategies to mitigate immune-related adverse events in immune checkpoint inhibitors therapy,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 17, 2026, https://archives.christuniversity.in/items/show/22470.

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