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Development of Biocompatible Barium peroxide/Pluronic F127/L-ornithine Composite for Enriched Antimicrobial, Antioxidant and Anticancer Potential: An in vitro Study
Osteosarcoma (MG-63) is a type of bone cancer affects mostly adolescents and young adults. Disease-causing microorganisms like Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Candida albicans pose serious illness in humans. There is a need to develop multifunctional composite to combat cancer and other most common disease caused by disease causing microorganisms. In this context, BaO2 and pluronic F127, L-Ornithine coated BaO2 (BaO2-PF127-LO) composite have been prepared and characterized by XRD, FTIR, UV-Vis, SEM, HRTEM, EDAX, and XPS analytical techniques. BaO2 and BaO2-PF127-LO were orthorhombic crystalline structure and the crystallite size was found as 32nm for BaO2 and 26nm for modified BaO2 PL studies revealed the green emission observed at 506nm for BaO2-PF127-LO composite which is absent in the case of bare BaO2. Antimicrobial activity of BaO2 and BaO2-PF127-LO was investigated. MTT assay was performed to determine the anticancer potential while the DPPH free radical scavenging assay was carried out to determine the antioxidant potential. The experiment study revealed that the BaO2-PF127-LO exhibited enhanced antimicrobial, antioxidant, and anticancer activity and low toxicity when compared to pristine BaO2. The experimental results revealed that the BaO2-PF127-LO composite holds promising potential for biomedical applications. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. -
Development of big data analytics for intelligent industrial manufacturing based on wireless and IOT technology /
Patent Number: 202141041225, Applicant: Mrs. Vaishali Gajendra Shende.
The global network interconnecting physical devices such as mechanical machines, sensors, computing devices, actuators, objects, smart applications and people is termed as Internet of Things (IoT) which has become significant part of several applications. In industrial applications, abundant amount of data is generated during the manufacturing process, which is heterogeneous, massive and time sensitive bringing substantial challenges in real time data collection, its processing and thereby decision making. In this invention, we develop a novel framework for big data analytics for intelligent industrial manufacturing based on Internet of Things for managing the huge data generated in industries for controlling smart manufacturing and for supporting online process of industrial monitoring. -
Development of an intelligent health monitoring system integrated with mobile application through IOT /
Patent Number: 202041053102, Applicant: Dr.A.Narasima Venkatesh.
An Intelligent health measuring system measures the vital health parameters like blood pressure, heart beat blood sugar, body position and temperature of the user or the patient. The non-invasive sensors are used to measure the health parameters easily without causing any disturbances to the patient or the user. -
Development of an intelligent health monitoring system integrated with mobile application through IOT /
Patent Number: 202041053102, Applicant: Dr.A.Narasima Venkatesh.
An Intelligent health measuring system measures the vital health parameters like blood pressure, heart beat blood sugar, body position and temperature of the user or the patient. The non-invasive sensors are used to measure the health parameters easily without causing any disturbances to the patient or the user. -
Development of an efficient real-time H.264/AVC advanced video compression encryption scheme
Multimedia is the combination of media such as text, graphics, video clips, and audio files. In todays world, multimedia plays an important role in many applications that we use in our daily lives. It is used in educational software, animation, sound, and text, as well as multi-media software. H.264/AVC video compression is extremely efficient in terms of compression. Despite this, H.264/AVC requires a lot of processing and consumes a lot of power insdespite of the fact that its compression efficiency is lower than that of H.264/AVC. We examine the various methods of Video H.264 Advanced Video Compression Standard Encryption Schemes in this paper. The performance of all types of encryption techniques will be evaluated using parameters such as cost overhead, delay, and encryption quality. This will provide us with a detailed comparative analysis of video encryption schemes, allowing us to determine which one is far more efficient for H.264/AVC. 2021 Taru Publications. -
Development of an Efficient and Secured E-Voting Mobile Application Using Android
Smart technologies, particularly the development of the Internet, are employed to enhance the quality of human existence. Thanks to the Internet's explosive expansion, more and more tasks can now be completed quickly and easily compared to the earlier times. E-voting is a relatively recent field that has been identified. Voting can be conducted in a variety of methods, including in person at a polling place, online, and via a mobile application. The security of applications cannot be disregarded given the internet's explosive growth. In order to prevent phishing attacks, we created an Android application and included a 3-step security process before voting. Students can now vote online from any location at any time using a mobile device. Android Studio is used to create and deploy the application. While creating the voting application, this research adheres to the software development life cycle. The result of this research is the creation of a mobile application that is user-friendly for students and serves as a practical tool for letting them vote with three levels of security. 2022 Anli Sherine et al. -
Development of a Supported Education Program for Students with Severe Mental Disorders in India
Background: The onset of severe mental disorders (SMDs) is during adolescence or young adulthood, which affects the well-being and the educational aspirations of the students. Models of supported education practiced in the West are not culturally suitable for Indian students or the Indian education system. This study aimed to develop a Supported Education Program (SEP) for students with SMDs to help them with academic reintegration in an Indian context. Methods and Material: To develop the SEP, a realist review was done, followed by an in-depth interview with eight mental health professionals (MHP) and nine lecturers, using a validated interview script. After each interview, interim analysis and modifications were done to improve the rigor of the interview. After all interviews, the SEP was circulated for a second round of iteration for consensual validation by four mental health experts. The outcome of the entire process was the final version of SEP for students with SMDs. Results: The final SEP had two broad themes and 18 subthemes from the qualitative thematic analysis: theme 1 included issues and strategies relevant to the client or caregivers, and theme 2 was pertinent to the education system. Conclusion: The SEP developed and validated for people with SMDs has distinctive components: one for the individual and caregiver and the other for the educational system. 2020 Indian Psychiatric Society - South Zonal Branch. -
Development of a scorecard to measure the satisfaction and happiness in higher education
This study aims to identify and test the antecedents affecting students' satisfaction and its relationship with happiness. A conceptual model was designed with the dimensions such as happiness, recognition, gratitude, physical health, and negative emotion to measure students' satisfaction. Martin Seligman's 'theory of well-being' was employed to measure the happiness of the students. Data was collected from 202 respondents and a structural equation modelling (SEM) approach was employed for analysis. The results of the study indicate that physical health, gratitude, and negative emotion influence the satisfaction of students in higher education. It was found that positive emotion and relationships have a significant influence on the happiness of the students. A relationship between satisfaction and happiness was developed. In extension to the present study's findings, a model and scorecard are proposed that can be used to measure the happiness and satisfaction of students in higher educational institutions in India. 2024 Inderscience Enterprises Ltd.. All rights reserved. -
Development of a fluorescent scaffold by utilizing quercetin template for selective detection of Hg2+: Experimental and theoretical studies along with live cell imaging
Quercetin is an important antioxidant with high bioactivity and it has been used as SARS-CoV-2 inhibitor significantly. Quercetin, one of the most abundant flavonoids in nature, has been in the spot of numerous experimental and theoretical studies in the past decade due to its great biological and medicinal importance. But there have been limited instances of employing quercetin and its derivatives as a fluorescent framework for specific detection of various cations and anions in the chemosensing field. Therefore, we have developed a novel chemosensor based on quercetin coupled benzyl ethers (QBE) for selective detection of Hg2+ with naked-eye colorimetric and turn-on fluorometric response. Initially QBE itself exhibited very weak fluorescence with low quantum yield (? = 0.009) due to operating photoinduced electron transfer (PET) and inhibition of excited state intramolecular proton transfer (ESIPT) as well as intramolecular charge transfer (ICT) within the molecule. But in presence of Hg2+, QBE showed a sharp increase in fluorescence intensity by 18-fold at wavelength 444 nm with high quantum yield (? = 0.159) for the chelation-enhanced fluorescence (CHEF) with coordination of Hg2+, which hampers PET within the molecule. The strong binding affinity of QBE towards Hg2+ has been proved by lower detection limit at 8.47 M and high binding constant value as 2 104 M?1. The binding mechanism has been verified by DFT study, Cyclic voltammograms and Jobs plot analysis. For the practical application, the binding selectivity of QBE with Hg2+ has been capitalized in physiological medium to detect intracellular Hg2+ levels in living plant tissue by using green gram seeds. Thus, employing QBE as a fluorescent chemosensor for the specific identification of Hg2+ will pave the way for a novel approach to simplifying the creation of various chemosensors based on quercetin backbone for the precise detection of various biologically significant analytes. 2024 Elsevier B.V. -
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Development of ?-carrageenan-based transparent and absorbent biodegradable films for wound dressing applications
Wound healing remains a critical challenge in healthcare, requiring advanced wound dressings with superior properties like transparency, absorbency, and biocompatibility. However, gaps exist in the use of marine-derived biopolymers for sustainable dressings. This study addresses this gap by combining ?-carrageenan (KC) with polyvinyl pyrrolidone (PVP) to develop transparent and absorbent biodegradable films through solvent casting and lyophilization techniques. Lyophilized films exhibited superior absorbency (9.17 g/cm2) and moisture management, with a water vapour transmission rate of 3990.67 g/m2/24 h, while solvent-cast films showed 78 % transmittance, enabling wound visualization. Mechanical testing revealed high tensile strength (31.5 MPa) and folding endurance (410 folds), ensuring durability. In vitro bactericidal assays confirmed efficacy against MRSA and E. coli, and in vivo tests on Wistar rats showed complete wound healing within 16 days with 91.1 % closure, outperforming untreated controls (76.7 %). This is the first study to explore lyophilized KC-PVP films for wound dressing applications, demonstrating potential for drug release, absorbency, and biodegradability. The innovative combination of biopolymers and fabrication techniques offers a sustainable, high-performance solution for wound care. 2024 Elsevier B.V. -
Development challenges for agriculture in Maharashtra
Maharashtra is heralded as one of the economically advanced states, but this illusion crashed under the attack of COVID-19 virus and economic deterioration is expected to follow. It is argued here that the state policy dished out a raw deal to the agricultural sector and set the sector under severe stress. The path of this retrogression, reasons behind the trends and the possible policy platform for the last six decades are traced. Stagnation has gripped the agricultural sector, and it is losing cultivable land to other uses. This is accompanied by a sharp increase in small and marginal holdings. Surprisingly, the state has no agricultural policy document in place and the sector largely depends on only sporadic firefighting approaches with a policy paralysis. 2020 Economic and Political Weekly. All rights reserved. -
Development and validation procedure of the higher educational facilities scale (HEFS)
Purpose: The purpose of this study was to develop and validate a scale to assess the influence of Higher Educational Facilities for the growth of education in higher education institutions. Design/methodology/approach: The first step in the process of scale development is to generate an item pool containing as many items as possible which captures the construct of interest. A total of 111 items were constructed for the initial try-out of the scale measuring the construct of higher educational facilities. This rating scale was based on the Likert-type was designed, where each item had to be rated on a five-point scale. The scale consisted of a few items involving the dimensions of infrastructure, quality assessment and quality assurance regard to the vision actualization. Findings: Higher Educational Facilities Scale (HEFS) was developed by the investigator and designed in the format of a 5-point rating scale of the Likert type. There are different phases identified for the scale construction. In the first phase, items are created and the contents validity is determined. The scale is constructed in the second phase. Pre-testing the questions, administering the survey, reducing the number of items and determining how many factors the scale captures are all steps in the scale construction process. The number of dimensions, reliability and validity are all verified in the third phase, scale evaluation. In developing the scale, the content and face validity was ascertained. The reliability of the scale and its three subscales were established. This scale has potential value for policymakers to assess the perception held by the religious faculty members working in higher education institutions. Originality/value: The research is part of the doctoral thesis by Dr Deepa Thomas under the supervision of Dr Fr. Joseph C. C. and the co-supervision of Dr Kennedy Andrew Thomas. The purpose of the scale is to assess the higher educational facilities of in institutions of higher Education. Quality, excellence and service are the vision and purpose of higher education institutions to provide ample opportunities and good facilities for their beneficiaries, thus creating tremendous changes in the Indian education scenario. 2024, Emerald Publishing Limited. -
Development and Validation of Work Environment Services Scale (WESS)
Purpose: This study presents a nine-factor, 32-item measure of work environment scale in the service sector. A healthy work environment is one in which employees trust the people they work for, have pride in what they do, and enjoy working with the people (Levering and Moskowitz, 2004). Methodology: This instrument builds on the conceptual model espoused by Insel and Moos (1974), Gordon (1973), Fletcher and Nusbaum (2010), Amabile et al. (1996), and Spector (2003). The scale included items elicited through a literature review, the use of the Delphi technique with a panel of experts, and tested on 824 full-time employees from nine service sector industries and five major cities in India. Findings: The Work Environment Services Scale (WESS) is a reliable and valid scale useful for measuring the nine work environment factors in the Indian services organization, with its own norms and a detailed manual. Originality/Value: The prevailing scales for measuring work environment do not capture the influence of ethics, recreation facilities, and the impact of social giving on the work environment. Most scales were suitable for sectors in the Western context, and there were no Indian scales measuring service employees' perception of their work environment. 2021 Harold Andrew Patrick et al., published by Sciendo 2021. -
Development and Validation of the UV-Spectrophotometric Method for the Determination of Cordycepin, a Nucleoside
The primary, bioactive component of Cordyceps militaris, known as cordycepin (3'-deoxyadenosine), has been utilized extensively as a traditional medicinal ingredient and a nutritious diet in Asian nations. To determine the amount of cordycepin in the C. militaris, high-performance liquid chromatography (HPLC) is shown to be an effective, sensitive, and straightforward analytical technique. Other methods for estimating cordycepin include near infrared spectroscopy and capillary electrophoresismass spectrometry. The UV-Vis spectroscopy approach was used to quantify cordycepin, and the results were statistically confirmed and compared with an HPLC method. For linearity, repeatability, precision, reproducibility, limit of detection and limit of quantification, the method was verified. The established approach can be utilized for routine, quality control analysis of cordycepin, as it is easy to use, sensitive, accurate, precise, repeatable, and most importantly, cost-effective. Springer Science+Business Media, LLC, part of Springer Nature 2024. -
Development and Validation of the Social Media Self-Esteem Scale for Adolescents
Development of the self is a vital aspect during the period of adolescence. Interaction with peers contributes to the development of various aspects of self. Due to the technological advances in todays times, adolescents interact with their peers through social media sites and portals. It is essential to study this development in light of the increasing use of social media by adolescence. Thus, the study aimed at developing an item pool to tap the construct of social media influencing self-esteem of adolescents following the procedure of tool construction. Participants included adolescents ranging between 16 to 18 years of age, who have at least one social media account for personal use. There were 110 participants for the first phase and 397 participants for the second phase of the study. The scale has eight items with the overall reliability of .7. It indicates a fitting measure of self-esteem influenced by social media, with looking-glass self theory, according to which individuals develop their self, based on their perceptions of others responses to their behaviour. Copyright 2020, IGI Global. -
Development and Validation of the Multidimensional Psychosocial Risk Screen (MPRS): An Approach towards Primary Prevention
Background: The prevalence of mental health problems in adolescents has been identified as a global concern. Early screening and identification can offer benefits in terms of primary prevention and reduced healthcare costs. This study aimed to develop a tool to assess the risk of developing mental health problems in adolescents. Methods: The study followed an exploratory sequential design and was divided into five phases. The Multidimensional Psychosocial Risk Screen (MPRS) is a newly developed self-report measure. The various steps in its development and validation have been elaborated. The MPRS was evaluated with a sample of 934 adolescents aged 12-18, spread across the 8th-12th grade. Results: Exploratory and confirmatory factor analyses revealed a robust factor structure. The extracted five factors were named as Parent-Child Relationship (PCR), Self-Concept (SC), Teacher-Student Dynamics (TSD), Social Media Use (SMU), and Peer Interaction (PI). The reliability of the subscales ranged from 0.60 to 0.80. The overall reliability of the scale was good (a = 0.87). Convergent validity of the scale was established using standard measures of risk factors and emotional and behavioural problems. Conclusions: The MPRS can be considered an effective tool with an adequate factor structure and good psychometric properties. It can be beneficial in the early detection of vulnerabilities to mental health problems in adolescents and, therefore, seen as a key element in primary prevention and fostering individualized interventions. 2023 The Author(s). -
Development and validation of superstitious beliefs scale
Superstitions though considered as irrational beliefs are widely prevalent in all cultures. Most of the existing work on superstitions are predominantly based on traditional western beliefs. The relevance of established superstition scales which are developed in western societies in collective societies need to explored. Interdependent nature of self which is a characteristic of collectivistic culture also has a role in belief formation. The present study aims at developing a new self-report measure of superstitious beliefs scale. Study 1, focused on exploring the factor structure and establishing reliability over a sample of 338 undergraduate students. The 17-item Superstitious Belief Scale (SBS) developed distinguishes a six-factor structure namely, Popular Beliefs, Belief in Good Luck, Belief in Bad Luck, Personal Superstitions and Social Superstitions. The six-factor structure was evaluated on a new sample (N = 483) using confirmatory factor analysis in Study 2. The internal consistency values of the new SBS over Studies 1 and 2 indicated high reliability. The findings have important implications for existing theory on superstitions. The new framework proposes and demonstrates the need to base the understanding of measurement of superstitious beliefs relevant in India. AesthetixMS 2020. -
Development and validation of multi-dimensional scale of grit
Positive psychology nurtures the potent qualities of individuals and aids them in carving a niche for themselves. Based on this theoretical foundation, a non-cognitive trait-like grit plays an imperative role in attaining high achievement. Previous studies have identified three dimensions of grit: perseverance of effort, consistency of interest and adaptability to situations. Recent research has criticized the dimension consistency of interest in a collectivist context. The present study provides an account of grit in view of eastern perspectives to check the suitability of the construct in India. Current findings provide a framework for the development and validation of Multi-Dimensional Scale of Grit reveals four dimensions of grit, namely, adaptability to situation, perseverance of effort, spirited initiative and steadfastness in adverse situations. It also provides an insight regarding the duration of goal attainment with respect to grit. The research conducted over three studies included Indian university students to develop and examine the psychometric properties of grit. Study 1 focused on item analysis and development of the factor structure through exploratory factor analysis. Study 2 confirmed the previously obtained factor structure through confirmatory factor analysis. In study 3, the psychometric properties of the scale were measured through test-retest reliability and validity, criterion, convergent and divergent. Results indicated that Multi-Dimensional Scale of Grit is a reliable and valid measure. It also indicated that the obtained 12 items and four dimensions were in synchronization with the relevant eastern perspective. 2021 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. -
Development and validation of middle school under performers checklist in India through virtual platforms post-COVID-19
Education is a holistic development that must be nurtured through hybrid or virtual educational practices. The pandemic brought a sense of psychosocial distress among teenagers that urged the need to understand these psychosocial competencies. Often, our Indian education system is unable to assess the challenging psychosocial competencies of learners in varied learning platforms. Hence, there is a need in todays context to harness adolescents holistic learning to be more flexible, and interactive with innovative instructional methodologies, creative assessment strategies, and virtual resource tools. These psychosocial open learning resources need to be advocated by educators and counsellors for the well-being of teenagers. Thus, this quantitative study aimed to develop a checklist to identify the psychosocial concerns of underperformers in an open learning system. Hence, educators and counsellors must be equipped to recognise their psychosocial concerns to handhold them into becoming autonomous thinkers and contributors in their society. This would further establish the seed of sustainability. Thus, this study aimed to develop and validate a checklist as a psychometric measure to identify middle school underperformers social and personal abilities. The study group comprised 359 school educators and counsellors in Bangalore and Mashed, India (299 educators and 60 counsellors). The checklist was developed using Develop (2016) and Oldenburgs principles of scale development (2021). The Cranach coefficient of the checklist was.924 for 12 items. The statistical results indicated the validation of the checklist as a tool for identifying psychosocial challenges of eighth-grade underperformers as reliable. Exploratory Factor Analysis reduced these items into two distinctive factors. The findings suggest that the checklist can be used as an innovative educational toolkit to identify middle school underperformers personal and social abilities. Further experimentation of this study can be taken up with a larger intergenerational population. 2025 selection and editorial matter, Asma Parveen and Rajesh Verma; individual chapters, the contributors.