Browse Items (11810 total)
Sort by:
-
In vitro propagation and secondary metabolite production from Withania Somnifera (L.) dunal
Withania somnifera (L.) Dunal, commonly known as ashwagandha or Indian ginseng, is an important medicinal plant that belongs to the family Solanaceae. Ashwagandha has been used from time immemorial in different systems of medicine and extensively used in the Indian system of medicine, and there is discussion of this plant in different ayurvedic scripts like Charaka samhita, Ashtanga sangraha, etc. The plant is extensively used for anti-aging and general well-being, and also has anti-cancer potential. Ashwagandha is also known for its antioxidant, anti-inflammatory, and other therapeutic activities. In the recent days of Covid-19, the plant has been extensively used as an immunostimulant. The plant has great potential for its raw materials, especially for the extraction of bioactive molecules like withanolide-A, withaferin-A, withasomniferin, withanone, etc. The conventional mode of propagation could not meet the required commercial demand for either the pharmaceutical industries or the traditional practitioners. The conventional method of obtaining biomass is influenced by a large number of environmental factors, where biomass quality and quantity of bioactive molecules have shown variation. To overcome this, biotechnological approaches such as plant tissue culture techniques have been established for large-scale cultivation using micropropagation and also other techniques like a callus and cell suspension culture, shoot culture, adventitious root culture, and hairy root culture have been extensively used for in vitro production of bioactive molecules from ashwagandha. With the advent of metabolic engineering, biosynthetic pathway editing has made it possible to obtain higher yields of desired metabolites. The present chapter focuses on the in vitro propagation, biosynthesis of withanolides, and tissue culture strategies for obtaining high biomass and metabolites. The chapter also focuses on different elicitation strategies, metabolic engineering approaches, and the development of elite germplasms for improved metabolite content. The chapter also identifies research lacunas that need to be addressed for the sustainable production of important bioactive molecules from ashwagandha. 2024 Bentham Science Publishers. All rights reserved. -
In vivo, in vitro and in silico screening of a potent Angiotensin Converting Enzyme (ACE) inhibitor from Trigonella foenum-graecum extract using Zebrafish as a model organism to reduce hypertension
The number of patients suffering from hypertension is on the rise worldwide and there is a need to explore natural products which can supplement current drugs to treat this disease. RAAS (Renin Angiotensin Aldosterone System) is one of the factors maintaining blood pressure. In the present investigation, we explored the potential of methanolic extract of fenugreek seeds in inhibiting Angiotensin Converting Enzyme (ACE), a key enzyme in the RAAS system, thereby reducing hypertension. In addition to in vivo studies conducted on zebrafish, in vitro and in silico studies were also performed to assess the inhibitory effect of the fenugreek extract on ACE. The bioactive components in Trigonella foenum-graecum revealed by GC-MS were further subjected to docking and binding studies with the receptor protein ACE. Of the various phytochemicals studied, arachidonic acid exhibited the maximum inhibitory effect on ACE. Thus, the present investigation was able to favorably screen a potent ACE inhibitor in Trigonella foenum-graecum extract which shows a potential to be used alone or supplemented with synthetic ACE inhibitors to treat high blood pressure. Further investigations are required to quantify the phytochemical for its inhibitory activity and also to understand the mechanism of inhibition of the enzyme. 2020 World Research Association. All rights reserved. -
In-Depth Review of Microeconomic Analysis of Business Tourist Spending
Most prior research used tourist arrivals to examine international tourism demand. However, tourist arrival is not an accurate factor to determine international tourism demand as it does not show the actual spending pattern of tourists which includes goods and services purchased. Literature has proven that business tourists always spend more than leisure tourists; thus, tourist expenditure is an essential measure of international tourism demand. For the current research, we summarised 31 studies to review several variables that could affect tourism demand and expenditure. The current research concludes that microeconomic modelling should be the focus and given priority for studying tourism demand and the factors that affect business tourist expenditure. The Author(s) 2018. -
In-phase, out-of-phase, bottom-wall two-frequency boundary temperature modulations on the onset of Rayleigh-Bard convection
The onset of convection in a Newtonian liquid-containing system is investigated using a two-frequency boundary temperature. The consequences of three types of two-frequency boundary temperature modulations have been thoroughly investigated: (i) in-phase, (ii) out-of-phase, and(iii) bottom-wall. The combined effect of two frequencies with sinusoidal and nonsinusoidal wave types is also documented under these various types of boundary temperature modulations. To facilitate the study, the Venezian method is approvedand the critical Rayleigh number and its correction are calculated. The parameters resulting from the study's two frequencies of modulation are the mixing angle, (Formula presented.), the amplitudes, (Formula presented.), and the set of coprime integers, (Formula presented.). The system's thermodynamics determines the range of these parameters. The research discovered that out-of-phase two-frequency boundary temperature modulation is the most stable, while in-phase is the least stable. Besides that, any combination of wave type with square wave type yields the most excellent stability. Furthermore, the two-frequency boundary temperature modulation is more stable than the single-frequency and no-modulation cases. 2022 Wiley Periodicals LLC. -
In-plant production of bricks containing waste foundry sandA study with Belgaum foundry industry
The main objective of this study is to utilize waste foundry sand (WFS) from Belgaum foundry industry in manufacturing of bricks. The process involved production of bricks in a fully functioning brick manufacturing plant, which has a production capacity of approximately 50000 bricks per month. The entire process of combining clay-sand mixtures, forming of bricks, drying and firing was done with local conditions. With minimum process it was possible to introduce upto 50% WFS in clay bodies to produce bricks of desirable properties. The minimum average wet compression resistance of 3.3 Mpa, and maximum average water absorption of 21.6% was obtained for bricks containing 50% WFS, when fired at 900 C. There was insignificant difference in apparent porosity, water absorption, and specific gravity of bricks containing WFS, when compared to commercial bricks. The addition of WFS reduced the bulk density of the bricks, which has also caused reduction in compressive strength. WFS bricks can be classified as class III bricks, based on recommendations of IS 1077 standard specification. These bricks can be used in single storied load bearing structures, and also in the construction of infill walls in multi-storied framed structures. The structure, composition, and morphology of the raw materials, as well as bricks were studied by XRD, XPS, and SEM, respectively. 2018 The Authors -
In-Vitro Investigation of the ?-Amylase Inhibition Activity of Bare Bis-Benzylidene-Cyclohexanone Synthesized by a Highly Selective Solvent-Free Route
Current work reports the highly selective, solvent-free synthesis of an endorsed bioactive compound, Bis benzylidine cyclohexanone (BBC) through solid acid catalysed cross aldol condensation route and checks its in-vitro bio activity. The catalytic support (Multiwalled carbon nanotube) employed was synthesized through the highly sophisticated catalytic chemical vapor deposition (CVD) method and simple mechanical grinding strategy was adopted to decorate sulfonic acid on the support. The C1s X-ray photoelectron peak of at 290.3 eV confirms the effective interaction of sulfonic acid with MWCNT. The sharp and intense desorption peaks observed at approximately 528.7 C and 655.15 C in the TPD analysis unmistakably substantiate the strong acidity of the synthesized system. The alpha amylase inhibition activity of the synthesized compound was calculated to be around 88.5 %, which is in par with the commercial drug as it could inhibit only 96 %. Further, the in-silico (Docking and Molecular Dynamic Simulation) investigations unveiled a new target site for the compound and this can further be studied in detail to advance the applications in drug design. Detailed scrutiny of various parameters was conducted to validate the bioactivity and pharmaceutical potential of the synthesized compound. 2023 Wiley-VCH GmbH. -
Inclined magnetic field and nanoparticle aggregation effects on thermal Marangoni convection in nanoliquid: A sensitivity analysis
The heat transfer rate of thermal Marangoni convection in ethylene glycol-based titanium nanoliquid is analyzed by using the Response Surface Methodology (RSM). Two different heat sources (i.e. the temperature-related heat source (THS) and the space-related exponential heat source (ESHS)) are included in the thermal analysis. Aggregation of nanoparticles and inclined magnetism are also considered. The modified Krieger-Dougherty model and the modified Maxwell-Bruggeman model are used to analyze the aggregation aspect of the nanoparticles. The resulting nonlinear system is treated numerically by using the finite difference method. The sensitivity of the heat transfer rate to the thermal radiation parameter, the ESHS parameter, and the THS parameter is examined by using the RSM model. The individual impact of the actual parameters on various flow fields is compared and visualized by graphs. The heat transfer rate is positively sensitive to thermal radiation and negatively sensitive to the parameters of the heat source. Besides, the ESHS aspect has a greater impact on the heat transfer rate than the THS aspect. The velocity flow field is decelerated significantly (5.31%near the interface) by the magnetic field inclination angle. 2020 The Physical Society of the Republic of China (Taiwan) -
Including category information as supplements in latent semantic analysis of Hindi documents
Latent semantic analysis (LSA) is a mathematical model that is used to capture the semantic structure of documents by using the correlations between the textual elements in them. LSA captures the semantic structure very well being independent of external sources of semantics. However, the model's performance increases when it is supplemented with extra information. The work presented in this paper is to modify the model to analyse word correlations in documents by considering the document category information as supplements in the process. This enhancement is called supplemented latent semantic analysis (SLSA). SLSA's performance is empirically evaluated in a document classification application by comparing the accuracies of classification against plain LSA for various term weighting schemes. An increment of 1.14%, 1.30% and 1.63% is observed in the classification accuracies when SLSA is compared with plain LSA for tf, idf and tfidf respectively in the initial term-bydocument matrix. Copyright 2017 Inderscience Enterprises Ltd. -
Inclusion of Sexual Health Education for the Wellbeing and Dignity of Secondary School Children: An Indian Rural Perspective
The study investigates students perspectives on incorporating sexual health education into the curriculum of secondary schools in rural Bangalore. Focused on assessing how such education impacts students physical and psychological well-being, confidence, and ability to make informed decisions, the research collected data from 981 students across 6th to 10th grades. A structured questionnaire, measured on a five-point Likert scale, explored students perceptions of sexual health education and its outcomes. After a meticulous data cleaning process, which included outlier removal, the study utilized a final sample of 900 students. IBM SPSS 25 and AMOS 25 facilitated the statistical analysis. The findings underscore the significant positive effect of sexual health education on students confidence levels. It highlights how this form of education aids in maintaining personal hygiene and fosters balanced decision-making skills among students. The studys results advocate for the implementation of sexual health education in schools, emphasizing its role in enhancing student wellbeing and confidence. Additionally, it contributes to defining the scope and framework of a sexual health education curriculum from the students perspective in rural Bangalore schools, aligning educational objectives with the actual needs and perceptions of the student body. 2023 Indian Institute of Health Management Research. -
Inclusive business approaches in tourism: Stakeholder engagement
The link between inclusivity and sustainability transcends economic considerations, extending into various dimensions such as gender equality, accessibility, cultural sensitivity, and community engagement. These dimensions underline that inclusivity is central to how tourism interacts with societies and ecosystems. This understanding prompts stakeholders to broaden their perspectives and integrate diverse viewpoints to create a more balanced and resilient industry. A central theme running through the chapters is the essential role of inclusivity in achieving a sustainable tourism sector. As the industry evolves, so do the expectations of travelers and communities. This heightened awareness and connectivity era demands that tourism entities proactively adapt strategies to foster inclusivity. Whether by creating accessible infrastructure, respecting local cultures, or integrating fairness into business models, inclusivity emerges as a foundation for lasting sustainability. The chapters compiled in this book offer a comprehensive exploration of inclusive tourism and sustainable development. In the context of the evolving global tourism landscape, these chapters illuminate various facets that shape the industry's present and future trajectories. These chapters reveal common themes and key insights, highlighting the importance of proactive measures, collaboration, and innovation to establish a more inclusive, equitable, and sustainable tourism sector. A prominent revelation throughout these chapters is the interconnectedness of inclusivity and sustainability in tourism. It becomes increasingly evident that sustainable tourism cannot be achieved without an inclusive framework that embraces diverse communities, stakeholders, and perspectives. The chapters illustrate how sustainability efforts lacking inclusivity can lead to inequality and overlook crucial factors shaping destinations' social and environmental aspects. 2024 by Nova Science Publishers, Inc. All rights reserved. -
Inclusive business models in tourism: A comprehensive analysis through the business model canvas
Tourism has become a cornerstone of global economic growth and cultural exchange, generating opportunities and challenges for various stakeholders. In recent years, there has been a growing emphasis on inclusive business practices within the tourism sector, aiming to create value not only for shareholders but also for local communities, marginalized groups, and the environment. This book chapter explores integrating inclusive principles into tourism business models and developing an Inclusive Business Model Canvas. The chapter begins by introducing the concept of inclusive business in the context of tourism and its significance in fostering sustainable development and social progress. It highlights the changing landscape of tourism, characterized by increased awareness of responsible travel, ethical considerations, and the need for equitable distribution of benefits. Subsequently, the chapter delves into the Business Model Canvas, a versatile tool for visualizing, analyzing, and designing business models. Each component of the canvas-Key Partnerships, Key Activities, Key Resources, Value Propositions, Customer Segments, Channels, Customer Relationships, Revenue Streams, and Cost Structure-is examined through the lens of inclusivity. This chapter comprehensively analyses how the Business Model Canvas can be employed as a strategic tool to guide the integration of inclusive practices into tourism businesses. It contributes to the growing body of literature on sustainable and responsible tourism, shedding light on innovative approaches that create value for businesses and communities. The chapter concludes by emphasizing the need for a holistic approach to inclusive business in tourism, highlighting the interconnectedness of the canvas components and the importance of aligning with the United Nations Sustainable Development Goals (SDGs). It also outlines future research directions and provides recommendations for businesses, policymakers, and stakeholders interested in fostering inclusive and sustainable tourism practices. 2024 Nova Science Publishers, Inc. All rights reserved. -
Inclusive innovation in tourism sector: Gap analysis through impact assessment
The travel and tourism industry is a major catalyst for global economic growth. Inclusivity and equity are indeed significant challenges faced by the service sector. The present study attempts to analyze the attributes of achieving true inclusivity and equity. This requires addressing systemic barriers and biases that can perpetuate unequal opportunities and outcomes towards building a pro-active tourism community. The chapter identifies the inequities already in place as well as untapped prospects for inclusive innovation in the tourism industry by performing an extensive gap analysis and impact assessment. A comprehensive and multi-faceted approach in practicing inclusiveness in the tourism sector demands an innovative pedagogy and unconventional business practices. The chapter highlights the bigger picture of inclusive innovation in tourism, which clarifies how business, society, and technology interact. A smart tourism approach with an integrated technological effort and socially-driven innovation builds the competency of the destinations. The study aims to assess the existing level of inclusion in tourism innovation, which determines significant representational and access gaps while assessing the potential economic and cultural effects of introducing more inclusive practices. As we navigate complex global challenges, from social inequality to environmental sustainability, inclusive innovation offers a path forward. The implications indicated in this chapter benefits the stakeholders with socially driven inclusive innovation. Towards inclusive innovation, equity takes center stage. An inclusive setting ensures collaboration and co-creation and integrating people from diverse backgrounds, including entrepreneurs, researchers, policymakers, and community members. Socially engaged stakeholders are aligned with inclusive innovation with insights and experiences, resulting in high relevance and sustainable orientation, thereby fostering growth and development. 2024 Nova Science Publishers, Inc. All rights reserved. -
INCLUSIVE LAW SCHOOL CLINICS: Institutionalizing Effective and Accountable Justice for All
Poor people are often denied access to the courts due to expensive legal fees. Preventing free access to justice violates a fundamental constitutional principle and universal international norms. The recognition of access to justice and the rule of law as outcomes and facilitators of sustainable development is a unique feature of the 2030 Agenda. This study shows that providing affordable and timely access to justice institutions and legal aid services will help achieve the Sustainable Development Goals (SDG) 16 targets of peace, justice, and strong institutions. Indian law school clinics have a unique opportunity to achieve the goal through institutionalized clinical legal education. The Advocates Act of 1961 requires an amendment to allow law students and faculty to represent pro bono clients. The study infers that completely institutionalizing the law school legal aid clinics as part of clinical legal education is a powerful platform to promote equal access to justice to all. 2021, Dharma Research Association. All rights reserved. -
Income Inequality in Globalization Context: Evidence from Global Data
This paper empirically investigates the relative effectiveness of economic globalization, trade openness, and financial openness on income inequality in low-, middle-, and high-income countries for the panel data over the period from 1991 to 2020 by endogenizing economic growth, urbanization, agriculture, industry, and service sectors value-added as % of GDP as control variables in income inequality function. The results emanating from the panel pooled mean group-autoregressive distributed lag (PMG-ARDL) test provide evidence of a significant long-run relationship among the variables. Interestingly, economic globalization reduces income inequality for high- and middle-income countries and increases it in low-income countries. On the other hand, trade openness reduces income inequality in high- and middle-income countries but increases it for low-income countries. In contrast, financial openness lessens income inequality in low-income countries but increases it for middle- and high-income countries. We find that urbanization increases income inequality in low-, middle- and high-income countries. We also find that economic growth decreases (increases) income inequality in high (middle and low)-income countries. Moreover, it is found that industrial and service sectors output decrease (increases) income inequality in high (middle and low)-income countries, whereas agricultural output improves (deteriorates) income distribution in middle- and low- (high) income countries. In light of these findings, we suggest that the governments of low-income countries need to focus more on improving the level of globalization and trade openness to improve their economic conditions in long run. Both high- and middle-income countries should also improve their financial openness so that effective utilization of overseas finance will flourish their overall economy. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. -
Incorporating the metaverse into the green banking revolution: Spearheading the implementation of eco-friendly financial practices
This study aims to explore the awareness and perceptions of green banking among bankers and customers in rural and semi-urban areas of India. A structured questionnaire was employed to gather information from 807 customers and 200 officials of selected commercial banks, utilizing the snowball sampling method. The study utilized chi-square and factor analysis techniques. The chi-square test results revealed an association between educational status and the customer's opinion regarding green banks. Factor analysis derived three key factors influencing the adoption of green banking: convenience and environmental sustainability, financial and technological advantages, and customer retention and prestige. The findings indicate that green banking services provide more benefits to its customers than traditional banking. 2024, IGI Global. -
Increasing involvement of artificial intelligence in healthcare with special reference to strokes /
International Journal of Emerging Technologies And Innovative Research, Vol.5, Issue 6, pp.746-751, ISSN No. 2349-5162. -
Increasing underutilised data in India: Opportunities and challenges
India, a country with a population of 1.33 billion has observed a substantial increase in the number of smart phones and internet users. This increase in internet users has not only changed the way Indian spend their time but has also led to generation of huge chunks of structured and unstructured data in India. In todays world where data of consumers is significant, this rise of internet users in India can change the game. This study focuses on how this increase in underutilised data in India, especially unstructured data can provide various opportunities and challenges to businesses, government and healthcare sectors in India. 2019 SERSC. -
Increasing usage of indirect advertisements and its effects /
Advertising is not at all a new term for the contemporary world. Brands have been using advertisements for the promotion and popularity. As an industry which needs a lot of creativity, advertising industry had undergone a lot of changes. According to the time and trend advertising industry found various changes and practised it. Here the researcher is trying to find out the latest trend in the advertising industry. -
INCREDIBLE INDIA TVC AND YOUTH TODAY
The paper deals with the television commercial of Incredible India. It studies whether these advertisements can be used to generate goodwill for the country. Incredible India advertisements are a rare combination of extraordinary words, music and visual. It is an initiative by the Government of India to promote tourism. They are small snippets capturing India at its best. The advertisement frequency is low. But if strategically used can prove beneficial in creating benevolence towards the country. The paper throws light on the negative treatment given to news by todays broadcast media. It analyzes whether the effect of it can be countered by the portrayal of beautiful India in the ??Incredible India advertisements. It studies if the result of viewing this advertisement can lead to overlooking of the flaws of our country. It specially tries to look into the effect that it might have on the youth. The methodology used for this study is experiment based. The researcher initially showed the respondents five television commercials and then followed it by distributing questionnaires which would help learn the consequences of viewing the advertisement. The limitation of the paper was the lack of journals, articles or related materials on the concerned topic. Nevertheless, considering all materials that were present, the research gave a holistic prospective to the advertising campaigns and its effect on the youth.