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Biocompatible NiTiO3Dopamine nanocomposites for combating drug-resistant pathogens through membrane disruption and oxidative stress
The rising threat of multidrug-resistant pathogens poses a challenge to public health. Highlighting the urgent need for novel antimicrobial agents, this study reports the synthesis of NiTiO3 nanoparticles and dopamine-functionalized NiTiO3 nanocomposites. Structural and elemental confirmation was obtained through XPS studies, which confirmed the presence of Ni2+ and Ti4+ in the nanocomposite, along with C 1s and O 1s peaks corresponding to dopamine coating. Photoluminescence spectra revealed that the NiTiO3dopamine nanocomposite exhibits notable green emission bands at 510, 518, and 527nm which arises from deep-level recombination associated with complex oxygen-related defects like oxygen vacancies. The NiTiO3-dopamine exhibited enhanced antimicrobial activity against S. aureus, B. subtilis, K. pneumoniae, S. dysenteriae, and C. albicans, compared to NiTiO3 alone. Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) assays further revealed that NiTiO3dopamine achieved MIC at 600?g/mL and MBC at 1000?g/mL for K. pneumoniae, outperforming pure NiTiO3. ROS assays confirmed oxidative stress-mediated antimicrobial action, with ROS levels significantly quenched in the presence of histidine. SEM images of bacterial morphology showed extensive membrane disruption in NiTiO3dopamine treated cells. Furthermore, zebrafish embryo assays confirmed excellent biocompatibility of the NiTiO3dopamine nanocomposite, with normal development observed up to 72h post fertilization. 2025 Published by Elsevier B.V. -
Chitosan and L-histidine coated biofunctional TiO? composite with enhanced ROS-mediated antimicrobial and anticancer efficacy for biomedical applications
Societies continue to face the urgent challenge of developing effective, safe, and stable nanoparticles with promising biomedical applications. Herein, the present study synthesis chitosan and L-Histidine dually coated titanium dioxide (TiCSLH) nanocomposite (NC) by chemical co-precipitation method. The antimicrobial performance of TiO? nanoparticles is closely linked to their physicochemical properties, such as reduced particle size, increased bandgap, and the presence of oxygen vacancies, all of which collectively enhance reactive oxygen species (ROS) generation and inhibit microbial growth. Structural analyses using XRD and TEM confirmed that TiCSLH nanoparticles possess an anatase phase and a spherical morphology. Compared to TiO?, TiCSLH nanoparticles demonstrated significantly enhanced antimicrobial activity against MRSA, E. coli, K. pneumoniae, P. aeruginosa and C. albicans strains, as evidenced by larger zones of inhibition from 2324mm. This enhanced efficacy is attributed to their smaller particle size (~ 26 3nm), wider bandgap (3.34eV), and prominent oxygen vacancy-related emissions at 518 and 531nm, which facilitate increased ROS production, resulting in cellular membrane disruption and microbial death. Furthermore, compared to TiO2, TiCSLH exhibited notable anticancer potential against breast cancer cells, with an IC?? of 10?g/mL, while maintaining excellent biocompatibility, as evidenced by its non-toxic response toward L929 fibroblast cells, which showed 83.5% cell viability. Collectively, these findings underscore the potential of TiCSLH nanoparticles for diverse biomedical applications. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025. -
Biocompatible Pluronic F127-coated nickel titanate nanoparticles: toward effective antimicrobial and antioxidant therapies
Multidrug-resistant bacterial infections are a major global health concern. Nickel titanate (NiTiO?) nanoparticles offer potential antimicrobial applications, but their biocompatibility is limited. This study explores the surface modification of NiTiO? with Pluronic F127 (PF127) to enhance biological performance. NiTiO? nanoparticles were synthesized and coated with PF127. Characterization was performed using XRD, FTIR, HRTEM, BET and DLS. Antibacterial activity was assessed via pathogenic bacteria assays and colony-forming unit quantification. Antioxidant activity was measured using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and zebrafish embryos evaluated in vivo toxicity. XRD confirmed hexagonal NiTiO?, and FTIR/HRTEM verified PF127 incorporation. BET analysis indicated a surface area of 28.66 m2 g?1 and mesoporous structure (2.59 nm pore diameter). DLS showed particle size reduction from 219.3 nm (NiTiO?) to 135.9 nm (NiTiO?PF127), confirming improved dispersion. NiTiO?PF127 exhibited enhanced antibacterial activity, with colony-forming unit counts decreasing in a concentration-dependent manner. The DPPH assay showed 53.7% radical scavenging at 20 ?g mL?1. Zebrafish embryo studies revealed higher viability and lower developmental toxicity for PF127-coated nanoparticles compared to uncoated NiTiO?. PF127 modification of NiTiO? improves dispersion, antibacterial and antioxidant activity, and biocompatibility. These results highlight NiTiO?PF127 nanocomposite as a promising candidate for biomedical and antimicrobial applications. 2026 Society of Chemical Industry. 2026 Society of Chemical Industry. -
NiFe2O3 and carboxymethyl cellulose modified NiFe2O3 nanoparticles: synthesis, antibacterial activity, and zebrafish embryo bio-evaluation
The alarming rise in multidrug-resistant bacterial infections has necessitated the development of novel and biocompatible antimicrobial agents. In this study, NiFe2O3 nanoparticles were prepared using co-precipitation method. The NiFe2O3 nanoparticles were functionalized with carboxymethyl cellulose to enhance their stability, dispersibility, and biological activity. The characterization results revealed that the CMC-modified NiFe2O3 nanoparticles exhibited an enhanced physicochemical property when compared to bare NiFe2O3. The hydrodynamic diameter of the CMC-modified NiFe2O3 nanoparticles were found to be 202.3 nm. The crystallite size of the nanoparticles was found to be 28.2 nm for NiFe2O3 and 24.3 nm for CMC-NiFe2O3. Fourier-transform infrared spectra revealed the effective functionalization of CMC through typical O[sbnd]H, C[sbnd]H, and C[sbnd]O[sbnd]C vibrations. The HRTEM results revealed the homogenous particle morphology with negligible aggregation. BET analysis indicated a high surface area of 85.75 m2/g and a pore volume of 1.789 cm3/g, showing a mesoporous structure. The optical studies demonstrated a narrowed band gap from 3.22 eV to 3.12 eV, and lower PL intensity, implying better charge separation and higher surface defects. Antibacterial activity, assessed by agar well diffusion method, indicated drastically bigger zones of inhibition for CMC-NiFe2O3 over bare NiFe2O3, against Shigella dysenteriae and Proteus vulgaris. The antioxidant activity of CMC-NiFe2O3 was determined through DPPH assay which demonstrated dose-dependent radical scavenging activity. The zebrafish embryo toxicity testing revealed dose-dependent developmental anomalies, with high doses (3 mg/mL) triggering pericardial edema, tail malformation, and reduced pigmentation. 2025 Elsevier B.V. -
Multifunctional Evaluation of CaCO3Sodium Alginate Nanocomposite for Antibacterial, Antifungal, and Anticancer Applications
In this study, Calcium carbonate (CaCO?) nanoparticles and calcium carbonatesodium alginate (CaCO?SA) nanocomposite were successfully synthesized via a controlled precipitation method and evaluated for multifunctional biomedical applications. Structural and surface analyses confirmed the formation of a calcite phase with effective surface functionalization using SA. The nanocomposite exhibited reduced crystallite size (~ 29nm vs. ~38nm for CaCO?), improved dispersion, and enhanced defect density, as evidenced by XRD, DLS, PL, and TEM analyses. PL studies revealed multiple defect-related emission bands (370534nm), indicating the presence of active surface states. The CaCO?SA nanocomposite demonstrated significantly enhanced antimicrobial activity compared to CaCO?, with zone of inhibition values reaching ~ 20mm (S. aureus), ~ 21mm (S. pneumoniae), ~ 20mm (E. coli), and ~ 18mm (C. albicans), comparable to standard drugs. CFU analysis confirmed a concentration-dependent reduction in bacterial viability, while MIC and MBC values were reduced to 500g mL? and 750g mL?, respectively, indicating improved bacteriostatic and bactericidal efficiency. In anticancer studies, the nanocomposite exhibited enhanced cytotoxicity against MG-63 osteosarcoma cells, reducing cell viability to ~ 30% at higher concentrations, while maintaining high biocompatibility of > 80% viability toward L929 fibroblast cells. Overall, this work highlights the potential of surface engineered CaCO? based nanomaterials as promising candidates for combined antimicrobial and anticancer applications, providing a foundation for future in-depth biological investigations and translational studies. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026. -
Green synthesis of biocompatible L-Histidine-Modified NiFe2O4 Nanoparticles: A multifaceted approach toward cancer and bacterial therapy
Cancer and infections caused by microbes remain serious global health threats, with multidrug resistance and toxicity associated with treatment constraining the efficacy of traditional therapies. In the present research, biocompatible L-histidine-functionalized nickel ferrite nanoparticles (NiFe2O4-LH) were green synthesized using of Clitoria ternatea flower extract and systematically evaluated for their therapeutic effects. Characterization established their spinel cubic structure, reduced crystallite size (14.4 nm), and enhanced stability when compared to bare NiFe2O4 (21.6 nm). UVvisible spectra revealed a blue shift with expanded band gap from 3.16 eV (NiFe2O4) to 3.92 eV (NiFe2O4-LH). The PL spectra revealed that the NiFe2O4-LH exhibited green emission at 516, 526 nm suggesting increased oxygen vacancies facilitating ROS production. The NiFe2O4-LH NPs demonstrated excellent antibacterial activity when compared to pure NiFe2O4. SEM analysis confirmed extensive bacterial membrane breakdown when exposed to NiFe2O4-LH. Cytotoxicity to MDA-MB-231 breast cancer cells showed a significant dose-dependent response with an IC50 of 12.41 ?g/mL. Biocompatibility assessments with zebrafish embryos supported negligible development toxicity, wherein NiFe?O?-LH-treated groups preserved normal morphology until 72 hpf compared to the bare NiFe2O4. 2025 Elsevier B.V. -
Biofunctional NiTiO3D-carvone nanocomposite: Synthesis, characterization, antibacterial, antioxidant, and zebrafish biocompatibility evaluation
The growing threat of microbial resistance and oxidative stress-related disorders highly demands the development of multifunctional nanoparticles with enhanced bioactivity and biocompatibility. In response to this demand, D-carvone functionalized nickel titanate (NiTiO?-D-carvone) was synthesized. XRD confirmed the formation of a crystalline rhombohedral NiTiO3 phase, while HRTEM revealed reduced agglomeration and uniform distribution upon D-carvone modification. The average crystallite size of the composite was 27 nm. DLS analysis showed a decreased hydrodynamic diameter (D?? = 112.50 nm) for the functionalized nanocomposite compared to bare NiTiO3 (225.70 nm). XPS spectra confirmed the presence of Ni? and Ti?? oxidation states, along with C=O and CO groups from D-carvone. The NiTiO3D-carvone nanocomposite exhibited a surface area of 2.658 m/g and showed strong UV absorption at 326 nm. PL studies revealed that the nanocomposite exhibited green emission at 524 nm, attributed to oxygen vacancy-related defect states which is favorable for enhanced ROS generation. Antibacterial studies demonstrated enhanced inhibition zones against K. pneumoniae (16 mm), S. dysenteriae (17 mm), Escherichia coli (18 mm) P. aeruginosa (12 mm) and P. vulgaris (17 mm) compared to bare NiTiO?. CFU assays revealed a concentration-dependent reduction in viable colonies, with the highest activity at 10 mg/mL. The antioxidant efficiency reached 61.4 % DPPH inhibition at 20 g/mL, closely comparable to Vitamin C (64.7 %). Zebrafish embryo assays confirmed excellent biocompatibility of the NiTiO?D-carvone system, with normal morphology and survival up to 96 hpf. The experimental results suggest that surface modification with D-carvone significantly enhances the biological activity and safety of NiTiO3 nanoparticles. 2025 -
Green synthesis of NiTiO? and tartaric acid-coated NiTiO? nanoparticles using Tagetes erecta: Characterization and biological applications
This study investigated the environmentally friendly synthesis, structural characterization, and biomedical potential of nickel titanate (NiTiO?) nanoparticles (NPs) prepared using Tagetes erecta (marigold) flower extract, with particular emphasis on their tartaric acid-coated, functionalized derivative (NiTiO?-T NPs). Structural analyses via FTIR spectroscopy revealed functional groups characteristic of the tartaric acid coating on NiTiO?-T NPs, while XRD confirmed the crystalline hexagonal phase for both NiTiO? and NiTiO?-T NPs. FESEM images demonstrated that both types of NPs exhibited uniform, spherical morphologies. Biomedical evaluations highlighted the enhanced efficacy of NiTiO?-T NPs, which achieved 85.2 % DPPH radical scavenging at 100 ?g/mL, significantly outperforming uncoated NiTiO? NPs (72.4 %). Antimicrobial testing against various pathogens showed that NiTiO?-T NPs generated larger inhibition zones compared to their counterparts, effectively targeting Gram-positive bacteria (S. aureus, B. subtilis), Gram-negative bacteria (E. coli, P. aeruginosa), and fungi (C. albicans). Further analysis revealed notably lower minimum inhibitory concentrations (MICs: 1000 ?g/mL) and minimum bactericidal concentrations (MBCs: 1500 ?g/mL) for NiTiO?-T NPs, confirming their potent bactericidal action. These findings position tartaric acid-functionalized NiTiO?-T NPs as promising candidates for dual-functional therapeutic applications. 2025 -
A study on role of cooperative banks in micro-finance with special reference to Karnataka /
The International Journal of Business & Management, Vol.4, Issue 10, pp.9-11, ISSN No: 2321-8916. -
Optimal portfolio construction with nifty stocks /
International Journal of Interdisciplinary and Multidisciplinary Studies, Vol.1, Issue 4, pp.474-480, ISSN No: 2348-0343. -
Exponential moving average - An algorithmic trading strategy /
International Journal of Research in Finance and Marketing, Vol.5, Issue 1, pp.14-22, ISSN No: 2231-5985. -
Bollinger bands optimal algorithmic strategyinstock trading /
International Journal of Research in Finance and Marketing, Vol.5, Issue 1, pp.37-45, ISSN No: 2231-5985. -
Technical analysis of equity shares /
International Journal of Research in Finance and Marketing, Vol.5, Issue 1, pp.23-29, ISSN No: 2231-5985. -
Human capital accounting /
International Journal of Research in Finance and Marketing, Vol.5, Issue 1, pp.30-36, ISSN No: 2231-5985. -
Exploring the impact of psychological biases on financial investment decisions and the role of digital financial literacy
This chapter explores biases impacting stock and mutual fund investments-cognitive, affective, and behavioral. It examines digital financial literacy (DFL), highlighting social media's role in information sharing. Stressing the merging financial and digital literacies, it addresses risks in online financial behavior. Discussions cover DFL measures, online activities' correlation, and biases in decision-making. Recognizing uncertainty in the digital era is crucial for informed financial decisions amidst evolving landscapes. 2024, IGI Global. All rights reserved. -
Implementing learner-centric approaches in high-density classrooms: A TEAMS-aligned hybrid model for management education
Learner-Centric Approaches (LCAs) are increasingly used in higher education to enhance engagement, critical thinking, and deeper learning. This chapter examines LCAs in a Bachelor of Business Administration (BBA) program at a large institution with class sizes of 80 students. To address challenges in personalized education, the program employs a hybrid model: large lectures for theory and smaller tutorial groups of 40 students for interactive LCAs. This approach balances personalized learning with logistical demands. The chapter evaluates the model's effectiveness through student outcomes, faculty adaptability, and engagement, while examining scalability and alignment with the TEAMS framework-Transparency, Empowerment, Attainability, Mentorship, and Sustainability. It offers practical insights for implementing scalable, learner-focused strategies in high-density classrooms. 2026, IGI Global Scientific Publishing. All rights reserved. -
Building inclusive workplace: Enhancing safety, security, and service quality to address workplace discrimination
This chapter examines the link between inclusivity, anti- discrimination efforts, and organizational performance through a study of IT employees from Northeast India, revealing workplace discrimination like racial stereotyping and exclusion. Such biases cause emotional distress, hinder career growth, and lower morale. Organizations must implement zero- tolerance policies, clear grievance mechanisms, and meritbased promotions to ensure fairness. Cross- cultural training fosters respect, breaks stereotypes, and strengthens team cohesion. Inclusive workplaces drive innovation, creativity, and productivity. Employees who feel valued contribute more effectively to organizational success. A holistic diversity strategy requires proactive leadership and continuous monitoring. Inclusivity is both an ethical imperative and a strategic asset for sustainable growth. 2026, IGI Global Scientific Publishing. All rights reserved. -
Development through ICT: A study on teachers perspectives on challenges in online education for tribal students amid COVID-19
Online education became an integral part of the education system during the COVID-19 pandemic. All the schools, colleges and universities adopted new technology in teaching-learning pedagogy. Academicians and students were taught to practice online education with many challenges and difficulties. The Constitution of India includes many beneficial provisions to promote the integral development of scheduled tribes. It enables them and protects them from socioeconomic status and forms of exploitation. In Kerala, the Scheduled Tribes Development Department is implementing various programs for the educational, social and economic development of Scheduled Tribes. Kerala is the most literate state in India. It creates a strong academic foundation at the school level. Even though the COVID-19 pandemic spread throughout the world, the government continued education in the state through the VICTERS educational television channel with the help of various ICT tools. This studys objective is to determine the challenges faced by tribal students in the Idukki District of Kerala State in online education and to understand the social and technological challenges they face in the learning process. An in-depth interview method was adopted for the study. This qualitative study explored the perspectives of teachers who teach tribal students. 2025 Malque Publishing. All rights reserved. -
Development through ICT: A study on teachers perspectives on challenges in online education for tribal students amid COVID-19
Online education became an integral part of the education system during the COVID-19 pandemic. All the schools, colleges and universities adopted new technology in teaching-learning pedagogy. Academicians and students were taught to practice online education with many challenges and difficulties. The Constitution of India includes many beneficial provisions to promote the integral development of scheduled tribes. It enables them and protects them from socioeconomic status and forms of exploitation. In Kerala, the Scheduled Tribes Development Department is implementing various programs for the educational, social and economic development of Scheduled Tribes. Kerala is the most literate state in India. It creates a strong academic foundation at the school level. Even though the COVID-19 pandemic spread throughout the world, the government continued education in the state through the VICTERS educational television channel with the help of various ICT tools. This studys objective is to determine the challenges faced by tribal students in the Idukki District of Kerala State in online education and to understand the social and technological challenges they face in the learning process. An in-depth interview method was adopted for the study. This qualitative study explored the perspectives of teachers who teach tribal students. 2025 Malque Publishing. All rights reserved. -
Enhancement of thermoelectric efficiency in vapor deposited Sb2Te3 and Sb1.8In0.2Te3 crystals
Crystal Research & Technology, Vol-49 (4), pp. 212-219. ISSN-0232-1300